(27 nodes) Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay network (Tetraodon nigroviridis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3DN45_TETNG	CBP80/20-dependent translation initiation factor. (619 aa)
	H3CNW9_TETNG	Mago homolog, exon junction complex subunit. (148 aa)
	H3DFW0_TETNG	Neuroblastoma amplified sequence. (2384 aa)
	H3DFG1_TETNG	SMG6 nonsense mediated mRNA decay factor. (1455 aa)
	H3DE96_TETNG	UPF3B regulator of nonsense mediated mRNA decay. (424 aa)
	Q4SSY8_TETNG	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (175 aa)
	H3CKN0_TETNG	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
	H3CJ69_TETNG	SMG9 nonsense mediated mRNA decay factor. (507 aa)
	H3DBX9_TETNG	UPF3A regulator of nonsense mediated mRNA decay. (377 aa)
	H3D9K9_TETNG	FATC domain-containing protein. (278 aa)
	H3D4R4_TETNG	PYM homolog 1, exon junction complex associated factor. (199 aa)
	H3D0H5_TETNG	Uncharacterized protein. (1126 aa)
	H3CZY0_TETNG	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (735 aa)
	H3CY72_TETNG	SMG5 nonsense mediated mRNA decay factor. (1121 aa)
	H3CQD7_TETNG	SMG8 nonsense mediated mRNA decay factor. (876 aa)
	H3CQ57_TETNG	Decapping mRNA 1B. (577 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1113 aa)
	H3C7Z3_TETNG	Decapping mRNA 1A. (578 aa)
	H3CAU2_TETNG	SMG7 nonsense mediated mRNA decay factor. (1154 aa)
	H3CB69_TETNG	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (413 aa)
	H3CBR9_TETNG	Uncharacterized protein. (2454 aa)
	UPF2	UPF2 regulator of nonsense mediated mRNA decay. (1238 aa)
	ENSTNIP00000007064	Antiviral helicase SKI2. (187 aa)
	H3CFI9_TETNG	SKI2 homolog, superkiller viralicidic activity 2-like. (1237 aa)
	H3CF87_TETNG	Decapping mRNA 2. (349 aa)
	H3CCP7_TETNG	Eukaryotic translation termination factor 1b. (442 aa)
	H3CC16_TETNG	Casc3 exon junction complex subunit. (670 aa)

Your Current Organism:

Tetraodon nigroviridis

NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTNIP00000007064	H3CBR9_TETNG	ENSTNIP00000007064	ENSTNIP00000005691	Antiviral helicase SKI2.	Uncharacterized protein.	0.766
ENSTNIP00000007064	H3CF87_TETNG	ENSTNIP00000007064	ENSTNIP00000006911	Antiviral helicase SKI2.	Decapping mRNA 2.	0.508
ENSTNIP00000007064	H3CKN0_TETNG	ENSTNIP00000007064	ENSTNIP00000008809	Antiviral helicase SKI2.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.447
ENSTNIP00000007064	H3D0H5_TETNG	ENSTNIP00000007064	ENSTNIP00000014011	Antiviral helicase SKI2.	Uncharacterized protein.	0.404
ENSTNIP00000007064	H3DBX9_TETNG	ENSTNIP00000007064	ENSTNIP00000018022	Antiviral helicase SKI2.	UPF3A regulator of nonsense mediated mRNA decay.	0.525
ENSTNIP00000007064	H3DE96_TETNG	ENSTNIP00000007064	ENSTNIP00000018839	Antiviral helicase SKI2.	UPF3B regulator of nonsense mediated mRNA decay.	0.525
ENSTNIP00000007064	UPF1	ENSTNIP00000007064	ENSTNIP00000002898	Antiviral helicase SKI2.	UPF1 RNA helicase and ATPase.	0.404
H3C7Z3_TETNG	H3CAU2_TETNG	ENSTNIP00000004365	ENSTNIP00000005364	Decapping mRNA 1A.	SMG7 nonsense mediated mRNA decay factor.	0.749
H3C7Z3_TETNG	H3CB69_TETNG	ENSTNIP00000004365	ENSTNIP00000005491	Decapping mRNA 1A.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.756
H3C7Z3_TETNG	H3CBR9_TETNG	ENSTNIP00000004365	ENSTNIP00000005691	Decapping mRNA 1A.	Uncharacterized protein.	0.706
H3C7Z3_TETNG	H3CC16_TETNG	ENSTNIP00000004365	ENSTNIP00000005788	Decapping mRNA 1A.	Casc3 exon junction complex subunit.	0.622
H3C7Z3_TETNG	H3CCP7_TETNG	ENSTNIP00000004365	ENSTNIP00000006020	Decapping mRNA 1A.	Eukaryotic translation termination factor 1b.	0.517
H3C7Z3_TETNG	H3CF87_TETNG	ENSTNIP00000004365	ENSTNIP00000006911	Decapping mRNA 1A.	Decapping mRNA 2.	0.993
H3C7Z3_TETNG	H3CJ69_TETNG	ENSTNIP00000004365	ENSTNIP00000008298	Decapping mRNA 1A.	SMG9 nonsense mediated mRNA decay factor.	0.790
H3C7Z3_TETNG	H3CKN0_TETNG	ENSTNIP00000004365	ENSTNIP00000008809	Decapping mRNA 1A.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.587
H3C7Z3_TETNG	H3CNW9_TETNG	ENSTNIP00000004365	ENSTNIP00000009952	Decapping mRNA 1A.	Mago homolog, exon junction complex subunit.	0.661
H3C7Z3_TETNG	H3CQ57_TETNG	ENSTNIP00000004365	ENSTNIP00000010391	Decapping mRNA 1A.	Decapping mRNA 1B.	0.960
H3C7Z3_TETNG	H3CQD7_TETNG	ENSTNIP00000004365	ENSTNIP00000010471	Decapping mRNA 1A.	SMG8 nonsense mediated mRNA decay factor.	0.855
H3C7Z3_TETNG	H3CY72_TETNG	ENSTNIP00000004365	ENSTNIP00000013207	Decapping mRNA 1A.	SMG5 nonsense mediated mRNA decay factor.	0.787
H3C7Z3_TETNG	H3CZY0_TETNG	ENSTNIP00000004365	ENSTNIP00000013816	Decapping mRNA 1A.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.461