STRINGSTRING
SPIDR SPIDR Q4TFX0_TETNG Q4TFX0_TETNG H3C986_TETNG H3C986_TETNG H3C9U8_TETNG H3C9U8_TETNG H3CBJ4_TETNG H3CBJ4_TETNG H3CCE7_TETNG H3CCE7_TETNG H3CCZ5_TETNG H3CCZ5_TETNG H3CE28_TETNG H3CE28_TETNG H3CEC6_TETNG H3CEC6_TETNG SLX1 SLX1 H3CIW7_TETNG H3CIW7_TETNG H3CJ40_TETNG H3CJ40_TETNG Q4SYN4_TETNG Q4SYN4_TETNG H3CJF1_TETNG H3CJF1_TETNG H3CJK2_TETNG H3CJK2_TETNG H3CKG5_TETNG H3CKG5_TETNG H3CKV5_TETNG H3CKV5_TETNG H3CL83_TETNG H3CL83_TETNG H3CL93_TETNG H3CL93_TETNG H3CLB0_TETNG H3CLB0_TETNG H3CLR4_TETNG H3CLR4_TETNG H3CMX3_TETNG H3CMX3_TETNG H3CN59_TETNG H3CN59_TETNG XRCC2 XRCC2 H3CP62_TETNG H3CP62_TETNG H3CP75_TETNG H3CP75_TETNG H3CR41_TETNG H3CR41_TETNG H3CR53_TETNG H3CR53_TETNG H3CRK6_TETNG H3CRK6_TETNG H3CS16_TETNG H3CS16_TETNG H3CSW2_TETNG H3CSW2_TETNG H3CSZ4_TETNG H3CSZ4_TETNG H3CTM4_TETNG H3CTM4_TETNG H3CTZ6_TETNG H3CTZ6_TETNG NIPBL NIPBL H3CV62_TETNG H3CV62_TETNG H3CVR6_TETNG H3CVR6_TETNG H3CWV5_TETNG H3CWV5_TETNG MCMDC2 MCMDC2 H3CY12_TETNG H3CY12_TETNG H3CY37_TETNG H3CY37_TETNG H3CYJ2_TETNG H3CYJ2_TETNG H3CYY0_TETNG H3CYY0_TETNG H3D061_TETNG H3D061_TETNG H3D204_TETNG H3D204_TETNG H3D3G8_TETNG H3D3G8_TETNG Q4S7M7_TETNG Q4S7M7_TETNG H3D3J1_TETNG H3D3J1_TETNG H3D401_TETNG H3D401_TETNG H3D4M7_TETNG H3D4M7_TETNG H3D5U1_TETNG H3D5U1_TETNG H3D5V9_TETNG H3D5V9_TETNG H3D5W7_TETNG H3D5W7_TETNG HUS1B HUS1B H3D860_TETNG H3D860_TETNG H3D8X2_TETNG H3D8X2_TETNG H3D913_TETNG H3D913_TETNG H3DBX0_TETNG H3DBX0_TETNG H3DCC8_TETNG H3DCC8_TETNG MCM7 MCM7 H3C3Y0_TETNG H3C3Y0_TETNG H3C2G7_TETNG H3C2G7_TETNG H3C0G9_TETNG H3C0G9_TETNG H3BZU9_TETNG H3BZU9_TETNG H3BXK0_TETNG H3BXK0_TETNG H3BWV6_TETNG H3BWV6_TETNG H3BW37_TETNG H3BW37_TETNG H3DES1_TETNG H3DES1_TETNG RPA1 RPA1 H3DFJ8_TETNG H3DFJ8_TETNG H3DIS1_TETNG H3DIS1_TETNG H3DIT7_TETNG H3DIT7_TETNG H3DJD9_TETNG H3DJD9_TETNG H3DJI7_TETNG H3DJI7_TETNG Q4RKH0_TETNG Q4RKH0_TETNG H3DLC8_TETNG H3DLC8_TETNG H3DLW9_TETNG H3DLW9_TETNG H3DMM4_TETNG H3DMM4_TETNG H3DMU6_TETNG H3DMU6_TETNG H3DP52_TETNG H3DP52_TETNG H3DP55_TETNG H3DP55_TETNG H3DPC1_TETNG H3DPC1_TETNG H3DPD5_TETNG H3DPD5_TETNG H3DPE0_TETNG H3DPE0_TETNG H3DPJ8_TETNG H3DPJ8_TETNG Q4R9Y5_TETNG Q4R9Y5_TETNG H3DR03_TETNG H3DR03_TETNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPIDRScaffold protein involved in DNA repair. (708 aa)
Q4TFX0_TETNGDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (231 aa)
H3C986_TETNGRING-type domain-containing protein. (309 aa)
H3C9U8_TETNGUncharacterized protein. (230 aa)
H3CBJ4_TETNGExonuclease 3'-5' domain containing 2. (546 aa)
H3CCE7_TETNGTAN domain-containing protein. (536 aa)
H3CCZ5_TETNGATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2313 aa)
H3CE28_TETNGUncharacterized protein. (251 aa)
H3CEC6_TETNGAdaptor related protein complex 5 subunit zeta 1. (798 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (265 aa)
H3CIW7_TETNGMUS81 structure-specific endonuclease subunit. (614 aa)
H3CJ40_TETNGMMS22L_C domain-containing protein. (347 aa)
Q4SYN4_TETNGChromosome undetermined SCAF12011, whole genome shotgun sequence; Belongs to the MCM family. (144 aa)
H3CJF1_TETNGHelicase, POLQ like. (837 aa)
H3CJK2_TETNGDNA_pol_B_exo1 domain-containing protein. (195 aa)
H3CKG5_TETNGRMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (487 aa)
H3CKV5_TETNGSAM domain and HD domain 1. (454 aa)
H3CL83_TETNGMinichromosome maintenance complex component 5. (640 aa)
H3CL93_TETNGDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (953 aa)
H3CLB0_TETNGDNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (202 aa)
H3CLR4_TETNGUncharacterized protein. (348 aa)
H3CMX3_TETNGRECA_2 domain-containing protein. (286 aa)
H3CN59_TETNGF-box DNA helicase 1. (841 aa)
XRCC2X-ray repair cross complementing 2. (283 aa)
H3CP62_TETNGATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (627 aa)
H3CP75_TETNGMCM domain-containing protein; Belongs to the MCM family. (397 aa)
H3CR41_TETNGDNA helicase; Belongs to the MCM family. (813 aa)
H3CR53_TETNGWD repeat domain 48b. (677 aa)
H3CRK6_TETNGRad21_Rec8_N domain-containing protein. (408 aa)
H3CS16_TETNGMMS22-like, DNA repair protein. (1206 aa)
H3CSW2_TETNGDNA helicase; Belongs to the MCM family. (860 aa)
H3CSZ4_TETNGZinc finger, SWIM-type containing 7. (137 aa)
H3CTM4_TETNGCtIP_N domain-containing protein. (637 aa)
H3CTZ6_TETNGNucleic acid binding protein 1a. (188 aa)
NIPBLNipped-B protein. (2448 aa)
H3CV62_TETNGDNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
H3CVR6_TETNGProteasome 26S subunit, non-ATPase 14. (309 aa)
H3CWV5_TETNGMinichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (751 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
H3CY12_TETNGUncharacterized protein. (1262 aa)
H3CY37_TETNGRAD51 paralog D. (325 aa)
H3CYJ2_TETNGRing finger and WD repeat domain 3. (512 aa)
H3CYY0_TETNGAdaptor related protein complex 5 subunit sigma 1. (190 aa)
H3D061_TETNGINO80 complex ATPase subunit. (566 aa)
H3D204_TETNGATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (956 aa)
H3D3G8_TETNGPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (572 aa)
Q4S7M7_TETNGChromosome undetermined SCAF14714, whole genome shotgun sequence. (155 aa)
H3D3J1_TETNGRAD52 homolog, DNA repair protein. (432 aa)
H3D401_TETNGUncharacterized protein. (833 aa)
H3D4M7_TETNGRAD21 cohesin complex component like 1. (518 aa)
H3D5U1_TETNGMethionine sulfoxide reductase B1b. (469 aa)
H3D5V9_TETNGExcision repair cross-complementation group 4. (895 aa)
H3D5W7_TETNGMeiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (285 aa)
H3D860_TETNGFanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (978 aa)
H3D8X2_TETNGFA complementation group B. (813 aa)
H3D913_TETNGSerine/threonine-protein phosphatase. (310 aa)
H3DBX0_TETNGRAD51 paralog C. (365 aa)
H3DCC8_TETNGStructural maintenance of chromosomes 5. (1096 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (728 aa)
H3C3Y0_TETNGBRCT domain-containing protein. (117 aa)
H3C2G7_TETNGTower domain-containing protein. (941 aa)
H3C0G9_TETNGDouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (671 aa)
H3BZU9_TETNGCell division cycle 7 homolog (S. cerevisiae). (552 aa)
H3BXK0_TETNGNSE1 homolog, SMC5-SMC6 complex component. (286 aa)
H3BWV6_TETNGDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
H3BW37_TETNGZgc:85936. (938 aa)
H3DES1_TETNGCDC45 cell division cycle 45 homolog (S. cerevisiae). (569 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
H3DFJ8_TETNGReplication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (613 aa)
H3DIS1_TETNGUncharacterized protein. (1918 aa)
H3DIT7_TETNGTonsoku-like, DNA repair protein. (1188 aa)
H3DJD9_TETNGDNA helicase; Belongs to the MCM family. (899 aa)
H3DJI7_TETNGRecQ helicase-like 4. (1465 aa)
Q4RKH0_TETNGChromosome 21 SCAF15029, whole genome shotgun sequence. (70 aa)
H3DLC8_TETNGReplication protein A3. (122 aa)
H3DLW9_TETNGNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
H3DMM4_TETNGRecQ mediated genome instability 2. (147 aa)
H3DMU6_TETNGZinc finger, FYVE domain containing 26. (2566 aa)
H3DP52_TETNGNSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (237 aa)
H3DP55_TETNGRAD21 cohesin complex component a. (634 aa)
H3DPC1_TETNGDNA helicase; Belongs to the MCM family. (802 aa)
H3DPD5_TETNGMCM domain-containing protein; Belongs to the MCM family. (193 aa)
H3DPE0_TETNGDNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
H3DPJ8_TETNGBLM RecQ like helicase. (1338 aa)
Q4R9Y5_TETNGChromosome undetermined SCAF24895, whole genome shotgun sequence; Belongs to the MCM family. (145 aa)
H3DR03_TETNGDNA_pol_B domain-containing protein. (177 aa)
Your Current Organism:
Tetraodon nigroviridis
NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish
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