(36 nodes) Embryonic hemopoiesis network (Tetraodon nigroviridis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	H3CRT3_TETNG	Bmi1 polycomb ring finger oncogene 1a. (314 aa)
	H3CRP3_TETNG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (664 aa)
	H3CRB9_TETNG	Nuclear receptor coactivator. (1439 aa)
	H3CPE0_TETNG	GATA binding protein 1a. (417 aa)
	H3CHU8_TETNG	T-box transcription factor 20. (436 aa)
	H3CFE0_TETNG	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1675 aa)
	H3CEZ6_TETNG	Tripartite motif containing 33. (753 aa)
	H3C919_TETNG	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa)
	H3C6Q1_TETNG	Activating transcription factor 4a. (390 aa)
	H3C6A1_TETNG	Homeobox domain-containing protein. (243 aa)
	Q4T7I8_TETNG	Chromosome undetermined SCAF8089, whole genome shotgun sequence. (64 aa)
	H3C099_TETNG	Chordin; Belongs to the chordin family. (951 aa)
	H3CNV3_TETNG	Metalloendopeptidase. (970 aa)
	H3BX30_TETNG	SH2B adaptor protein 3. (497 aa)
	H3BVZ1_TETNG	T-cell acute lymphocytic leukemia 1. (370 aa)
	H3CJG0_TETNG	5-aminolevulinate synthase. (604 aa)
	H3CIX7_TETNG	Uncharacterized protein. (257 aa)
	H3CIR6_TETNG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (665 aa)
	H3CLW2_TETNG	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (563 aa)
	H3DPZ2_TETNG	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
	H3DNY5_TETNG	Yes-associated protein 1. (307 aa)
	H3DM61_TETNG	Histone deacetylase 9b. (580 aa)
	H3DKV1_TETNG	Protein kinase C, alpha, b; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (603 aa)
	H3DKH1_TETNG	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
	Q4RMK4_TETNG	Chromosome 10 SCAF15019, whole genome shotgun sequence. (380 aa)
	H3DGV3_TETNG	Isthmin 1. (447 aa)
	H3DF59_TETNG	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1508 aa)
	H3DF37_TETNG	LIM domain only 2 (rhombotin-like 1). (159 aa)
	H3D9E7_TETNG	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (321 aa)
	H3D9E6_TETNG	Phorbol-ester/DAG-type domain-containing protein. (56 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (559 aa)
	H3CZR0_TETNG	Metalloendopeptidase. (879 aa)
	H3CZQ2_TETNG	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
	H3CYT8_TETNG	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
	H3CRY5_TETNG	Nuclear receptor coactivator. (1476 aa)

Your Current Organism:

Tetraodon nigroviridis

NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3BVZ1_TETNG	H3CPE0_TETNG	ENSTNIP00000000153	ENSTNIP00000010123	T-cell acute lymphocytic leukemia 1.	GATA binding protein 1a.	0.882
H3BVZ1_TETNG	H3DF37_TETNG	ENSTNIP00000000153	ENSTNIP00000019131	T-cell acute lymphocytic leukemia 1.	LIM domain only 2 (rhombotin-like 1).	0.991
H3C099_TETNG	H3CNV3_TETNG	ENSTNIP00000001665	ENSTNIP00000009936	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.856
H3C099_TETNG	H3CZR0_TETNG	ENSTNIP00000001665	ENSTNIP00000013746	Chordin; Belongs to the chordin family.	Metalloendopeptidase.	0.856
H3CEZ6_TETNG	H3CIX7_TETNG	ENSTNIP00000006820	ENSTNIP00000008205	Tripartite motif containing 33.	Uncharacterized protein.	0.900
H3CFE0_TETNG	H3CPE0_TETNG	ENSTNIP00000006964	ENSTNIP00000010123	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	GATA binding protein 1a.	0.456
H3CFE0_TETNG	H3CRB9_TETNG	ENSTNIP00000006964	ENSTNIP00000010803	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.565
H3CFE0_TETNG	H3CRY5_TETNG	ENSTNIP00000006964	ENSTNIP00000011019	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.565
H3CIX7_TETNG	H3CEZ6_TETNG	ENSTNIP00000008205	ENSTNIP00000006820	Uncharacterized protein.	Tripartite motif containing 33.	0.900
H3CJG0_TETNG	H3CPE0_TETNG	ENSTNIP00000008389	ENSTNIP00000010123	5-aminolevulinate synthase.	GATA binding protein 1a.	0.529
H3CJG0_TETNG	H3CZQ2_TETNG	ENSTNIP00000008389	ENSTNIP00000013738	5-aminolevulinate synthase.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.560
H3CNV3_TETNG	H3C099_TETNG	ENSTNIP00000009936	ENSTNIP00000001665	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.856
H3CNV3_TETNG	H3DNY5_TETNG	ENSTNIP00000009936	ENSTNIP00000022234	Metalloendopeptidase.	Yes-associated protein 1.	0.647
H3CPE0_TETNG	H3BVZ1_TETNG	ENSTNIP00000010123	ENSTNIP00000000153	GATA binding protein 1a.	T-cell acute lymphocytic leukemia 1.	0.882
H3CPE0_TETNG	H3CFE0_TETNG	ENSTNIP00000010123	ENSTNIP00000006964	GATA binding protein 1a.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.456
H3CPE0_TETNG	H3CJG0_TETNG	ENSTNIP00000010123	ENSTNIP00000008389	GATA binding protein 1a.	5-aminolevulinate synthase.	0.529
H3CPE0_TETNG	H3DF37_TETNG	ENSTNIP00000010123	ENSTNIP00000019131	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.972
H3CPE0_TETNG	H3DGV3_TETNG	ENSTNIP00000010123	ENSTNIP00000019747	GATA binding protein 1a.	Isthmin 1.	0.606
H3CRB9_TETNG	H3CFE0_TETNG	ENSTNIP00000010803	ENSTNIP00000006964	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.565
H3CRY5_TETNG	H3CFE0_TETNG	ENSTNIP00000011019	ENSTNIP00000006964	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.565