(49 nodes) Iron ion homeostasis network (Tetraodon nigroviridis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3CMY9_TETNG	ATPase H+ transporting accessory protein 1a. (475 aa)
	H3CKM9_TETNG	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (731 aa)
	Q4SWW3_TETNG	Chromosome undetermined SCAF13456, whole genome shotgun sequence. (188 aa)
	H3DN72_TETNG	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	H3DM67_TETNG	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (536 aa)
	H3DM14_TETNG	STEAP family member 4. (468 aa)
	H3DM13_TETNG	STEAP4 metalloreductase. (394 aa)
	H3DLC0_TETNG	Ferric-chelate reductase 1a. (592 aa)
	H3DKH1_TETNG	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (571 aa)
	H3DJX9_TETNG	F-box and leucine-rich repeat protein 5. (694 aa)
	H3DHQ9_TETNG	Cytochrome b reductase 1. (282 aa)
	H3CWJ8_TETNG	Heme oxygenase 2b. (284 aa)
	H3DEL0_TETNG	Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
	H3CU75_TETNG	ATP-binding cassette, sub-family B (MDR/TAP), member 7. (694 aa)
	H3CTF0_TETNG	Solute carrier family 25 member 28; Belongs to the mitochondrial carrier (TC 2.A.29) family. (378 aa)
	H3CSQ2_TETNG	Aconitase domain-containing protein. (249 aa)
	SLC11A2	Solute carrier family 11 member 2. (554 aa)
	H3CMK6_TETNG	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (425 aa)
	H3DED9_TETNG	Reelin domain-containing protein. (195 aa)
	H3D901_TETNG	Transferrin-like domain-containing protein. (229 aa)
	H3DB59_TETNG	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (714 aa)
	H3DC47_TETNG	Uncharacterized protein. (219 aa)
	H3DCQ4_TETNG	Transferrin-a. (469 aa)
	H3DD26_TETNG	Solute carrier family 39 member 14. (411 aa)
	H3CIC3_TETNG	BTB (POZ) domain containing 9. (609 aa)
	H3CI89_TETNG	Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (890 aa)
	H3CHE5_TETNG	Mothers against decapentaplegic homolog. (568 aa)
	H3CF94_TETNG	Uncharacterized protein. (213 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
	H3CUK0_TETNG	Iron-sulfur cluster assembly enzyme b; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (165 aa)
	H3CUH4_TETNG	Mothers against decapentaplegic homolog. (533 aa)
	H3D6Y8_TETNG	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (442 aa)
	H3D5R6_TETNG	Eukaryotic translation initiation factor 2-alpha kinase 1. (572 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (617 aa)
	H3D4H8_TETNG	ATPase H+ transporting accessory protein 1b. (449 aa)
	H3D0P3_TETNG	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (176 aa)
	H3CZY4_TETNG	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1147 aa)
	H3CZW2_TETNG	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
	H3CZQ2_TETNG	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
	H3CYY9_TETNG	3-hydroxybutyrate dehydrogenase, type 2. (197 aa)
	H3CYW7_TETNG	Solute carrier family 39 member 8. (392 aa)
	H3CY66_TETNG	BolA family member 1; Belongs to the BolA/IbaG family. (122 aa)
	H3CXD7_TETNG	Uncharacterized protein. (617 aa)
	H3CX77_TETNG	Hephaestin-like 1b; Belongs to the multicopper oxidase family. (1064 aa)
	H3CB53_TETNG	Uncharacterized protein. (127 aa)
	H3C668_TETNG	Ceruloplasmin; Belongs to the multicopper oxidase family. (1085 aa)
	H3CC01_TETNG	Mothers against decapentaplegic homolog. (510 aa)
	H3D784_TETNG	Nuclear receptor coactivator 4. (570 aa)
	STEAP3	Chromosome 3 SCAF15117, whole genome shotgun sequence. (491 aa)

Your Current Organism:

Tetraodon nigroviridis

NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6V1A	H3CMY9_TETNG	ENSTNIP00000015697	ENSTNIP00000009620	ATPase H+ transporting V1 subunit A.	ATPase H+ transporting accessory protein 1a.	0.895
ATP6V1A	H3CZW2_TETNG	ENSTNIP00000015697	ENSTNIP00000013798	ATPase H+ transporting V1 subunit A.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.969
ATP6V1A	H3D4H8_TETNG	ENSTNIP00000015697	ENSTNIP00000015416	ATPase H+ transporting V1 subunit A.	ATPase H+ transporting accessory protein 1b.	0.902
ATP6V1A	H3DN72_TETNG	ENSTNIP00000015697	ENSTNIP00000021971	ATPase H+ transporting V1 subunit A.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.995
FTH1	H3CB53_TETNG	ENSTNIP00000006889	ENSTNIP00000005475	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Uncharacterized protein.	0.428
FTH1	H3CF94_TETNG	ENSTNIP00000006889	ENSTNIP00000006918	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Uncharacterized protein.	0.583
FTH1	H3CWJ8_TETNG	ENSTNIP00000006889	ENSTNIP00000012632	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Heme oxygenase 2b.	0.410
FTH1	H3D0P3_TETNG	ENSTNIP00000006889	ENSTNIP00000014079	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.907
FTH1	H3D784_TETNG	ENSTNIP00000006889	ENSTNIP00000016375	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Nuclear receptor coactivator 4.	0.906
FTH1	H3DKH1_TETNG	ENSTNIP00000006889	ENSTNIP00000021017	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.461
FTH1	SLC11A2	ENSTNIP00000006889	ENSTNIP00000009880	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Solute carrier family 11 member 2.	0.428
H3C668_TETNG	H3CF94_TETNG	ENSTNIP00000003738	ENSTNIP00000006918	Ceruloplasmin; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.933
H3C668_TETNG	H3D6Y8_TETNG	ENSTNIP00000003738	ENSTNIP00000016279	Ceruloplasmin; Belongs to the multicopper oxidase family.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.406
H3C668_TETNG	H3DKH1_TETNG	ENSTNIP00000003738	ENSTNIP00000021017	Ceruloplasmin; Belongs to the multicopper oxidase family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.684
H3C668_TETNG	H3DM67_TETNG	ENSTNIP00000003738	ENSTNIP00000021615	Ceruloplasmin; Belongs to the multicopper oxidase family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.668
H3CB53_TETNG	FTH1	ENSTNIP00000005475	ENSTNIP00000006889	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.428
H3CB53_TETNG	H3CF94_TETNG	ENSTNIP00000005475	ENSTNIP00000006918	Uncharacterized protein.	Uncharacterized protein.	0.428
H3CB53_TETNG	H3CU75_TETNG	ENSTNIP00000005475	ENSTNIP00000011809	Uncharacterized protein.	ATP-binding cassette, sub-family B (MDR/TAP), member 7.	0.413
H3CB53_TETNG	H3D0P3_TETNG	ENSTNIP00000005475	ENSTNIP00000014079	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.428
H3CF94_TETNG	FTH1	ENSTNIP00000006918	ENSTNIP00000006889	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.583