(53 nodes) TCR signaling network (Tetraodon nigroviridis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3CDM8_TETNG	Non-specific serine/threonine protein kinase. (541 aa)
	H3CCP6_TETNG	F-box and WD repeat domain containing 11b. (526 aa)
	H3CC38_TETNG	Tyrosine-protein kinase. (567 aa)
	H3CAJ1_TETNG	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (686 aa)
	H3CDZ8_TETNG	Phosphoinositide phospholipase C. (895 aa)
	H3CE55_TETNG	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	H3CEC5_TETNG	Uncharacterized protein. (845 aa)
	H3CJ52_TETNG	Mitogen-activated protein kinase kinase kinase 7. (610 aa)
	H3CJ64_TETNG	Ig-like domain-containing protein. (194 aa)
	ENSTNIP00000008523	Unnamed protein product. (58 aa)
	H3CKE5_TETNG	Unnamed protein product; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (407 aa)
	Q4SUX4_TETNG	Chromosome undetermined SCAF13836, whole genome shotgun sequence. (169 aa)
	H3CLY6_TETNG	Spinster homolog 1 (Drosophila). (479 aa)
	H3CM88_TETNG	Uncharacterized protein. (150 aa)
	H3CN31_TETNG	Non-specific serine/threonine protein kinase. (548 aa)
	H3CQW2_TETNG	Receptor-interacting serine-threonine kinase 2. (572 aa)
	H3CT23_TETNG	Spinster homolog 3 (Drosophila). (478 aa)
	H3CUQ9_TETNG	SH3 domain-containing protein. (467 aa)
	H3CW38_TETNG	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (553 aa)
	H3CWF5_TETNG	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
	PAK3	Non-specific serine/threonine protein kinase. (546 aa)
	Q4SF14_TETNG	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	H3D0J6_TETNG	Protein kinase domain-containing protein. (445 aa)
	H3D112_TETNG	GRB2 related adaptor protein 2a. (325 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (766 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	H3D3M2_TETNG	Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	H3D4J6_TETNG	Uncharacterized protein. (303 aa)
	H3D527_TETNG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
	H3D5L6_TETNG	3-phosphoinositide dependent protein kinase 1b. (562 aa)
	H3D717_TETNG	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (412 aa)
	H3D8D0_TETNG	SH2 domain-containing protein. (105 aa)
	H3D8W2_TETNG	Immunoglobulin superfamily, member 3. (537 aa)
	H3D8W3_TETNG	Uncharacterized protein. (806 aa)
	H3DDE6_TETNG	MALT paracaspase 2. (683 aa)
	H3DDQ7_TETNG	MALT paracaspase 1. (697 aa)
	H3DER0_TETNG	Inhibitor of nuclear factor kappa B kinase subunit beta. (742 aa)
	H3DF41_TETNG	Tyrosine-protein kinase. (450 aa)
	H3DGJ8_TETNG	Component of inhibitor of nuclear factor kappa B kinase complex. (705 aa)
	H3DHS1_TETNG	Uncharacterized protein. (801 aa)
	H3DJS8_TETNG	Non-specific serine/threonine protein kinase. (530 aa)
	H3DMA3_TETNG	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	H3DMG3_TETNG	Uncharacterized protein. (744 aa)
	Q4RGY9_TETNG	Chromosome undetermined SCAF15083, whole genome shotgun sequence. (140 aa)
	H3DPK0_TETNG	MALT paracaspase 3. (598 aa)
	PAK2	Non-specific serine/threonine protein kinase. (509 aa)
	H3C7M0_TETNG	Uncharacterized protein. (323 aa)
	H3C633_TETNG	Immunoglobulin superfamily, member 3. (433 aa)
	H3C5R3_TETNG	Ig_4 domain-containing protein. (171 aa)
	H3C3J7_TETNG	Uncharacterized protein. (208 aa)
	H3BYW0_TETNG	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1273 aa)
	H3BYP0_TETNG	Ig-like domain-containing protein. (85 aa)
	H3C8R9_TETNG	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1241 aa)

Your Current Organism:

Tetraodon nigroviridis

NCBI taxonomy Id: 99883
Other names: T. nigroviridis, spotted green pufferfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	H3CAJ1_TETNG	ENSTNIP00000014802	ENSTNIP00000005263	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.732
CHUK	H3CCP6_TETNG	ENSTNIP00000014802	ENSTNIP00000006019	Component of inhibitor of nuclear factor kappa B kinase complex.	F-box and WD repeat domain containing 11b.	0.553
CHUK	H3CE55_TETNG	ENSTNIP00000014802	ENSTNIP00000006529	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.568
CHUK	H3CEC5_TETNG	ENSTNIP00000014802	ENSTNIP00000006599	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.627
CHUK	H3CJ52_TETNG	ENSTNIP00000014802	ENSTNIP00000008281	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.615
CHUK	H3CQW2_TETNG	ENSTNIP00000014802	ENSTNIP00000010646	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor-interacting serine-threonine kinase 2.	0.415
CHUK	H3CW38_TETNG	ENSTNIP00000014802	ENSTNIP00000012472	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.825
CHUK	H3CWF5_TETNG	ENSTNIP00000014802	ENSTNIP00000012589	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.568
CHUK	H3D0J6_TETNG	ENSTNIP00000014802	ENSTNIP00000014032	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.615
CHUK	H3D3M2_TETNG	ENSTNIP00000014802	ENSTNIP00000015110	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.	0.491
CHUK	H3D5L6_TETNG	ENSTNIP00000014802	ENSTNIP00000015805	Component of inhibitor of nuclear factor kappa B kinase complex.	3-phosphoinositide dependent protein kinase 1b.	0.505
CHUK	H3DDE6_TETNG	ENSTNIP00000014802	ENSTNIP00000018539	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 2.	0.423
CHUK	H3DDQ7_TETNG	ENSTNIP00000014802	ENSTNIP00000018650	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.423
CHUK	H3DER0_TETNG	ENSTNIP00000014802	ENSTNIP00000019003	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.524
CHUK	H3DGJ8_TETNG	ENSTNIP00000014802	ENSTNIP00000019642	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.414
CHUK	H3DHS1_TETNG	ENSTNIP00000014802	ENSTNIP00000020065	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.615
CHUK	H3DMA3_TETNG	ENSTNIP00000014802	ENSTNIP00000021651	Component of inhibitor of nuclear factor kappa B kinase complex.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.491
CHUK	H3DPK0_TETNG	ENSTNIP00000014802	ENSTNIP00000022449	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.423
CHUK	Q4RGY9_TETNG	ENSTNIP00000014802	ENSTNIP00000021867	Component of inhibitor of nuclear factor kappa B kinase complex.	Chromosome undetermined SCAF15083, whole genome shotgun sequence.	0.592
CHUK	Q4SF14_TETNG	ENSTNIP00000014802	ENSTNIP00000013085	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.632