(112 nodes) RAB GEFs exchange GTP for GDP on RABs network (Urocitellus parryii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	RIC1	RIC1 homolog, RAB6A GEF complex partner 1. (1421 aa)
	GAPVD1	GTPase activating protein and VPS9 domains 1. (1487 aa)
	MADD	MAP kinase activating death domain. (1628 aa)
	DENND5B	DENN domain containing 5B. (1331 aa)
	DENND6A	DENN domain containing 6A. (608 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
	RAB7B	RAB7B, member RAS oncogene family. (199 aa)
	MORN4	MORN repeat containing 4. (146 aa)
	ENSUPAP00010019071	annotation not available (203 aa)
	JPH3	Junctophilin 3. (748 aa)
	RAB5B	RAB5B, member RAS oncogene family. (215 aa)
	DENND4B	DENN domain containing 4B. (1495 aa)
	TRAPPC2L	Trafficking protein particle complex 2 like. (240 aa)
	DENND2A	DENN domain containing 2A. (968 aa)
	TRAPPC1	Trafficking protein particle complex 1. (145 aa)
	ALS2CL	ALS2 C-terminal like. (970 aa)
	VPS9D1	VPS9 domain containing 1. (628 aa)
	ENSUPAP00010020560	annotation not available (199 aa)
	DENND2D	DENN domain containing 2D. (476 aa)
	ENSUPAP00010020697	annotation not available (410 aa)
	ENSUPAP00010020720	annotation not available (224 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	WDR54	WD repeat domain 54. (349 aa)
	RAB35	RAB35, member RAS oncogene family. (201 aa)
	TRAPPC3	Trafficking protein particle complex 3. (180 aa)
	RGP1	RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (708 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon. (255 aa)
	TRAPPC5	Trafficking protein particle complex 5. (188 aa)
	AKT3	AKT serine/threonine kinase 3. (479 aa)
	AKT1	AKT serine/threonine kinase 1. (480 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	DENND1B	DENN domain containing 1B. (761 aa)
	Trappc10	Trafficking protein particle complex 10. (1259 aa)
	GRIPAP1	GRIP1 associated protein 1. (841 aa)
	RAB6A	RAB6A, member RAS oncogene family. (208 aa)
	RAB27A	RAB27A, member RAS oncogene family. (220 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	RSPH1	Radial spoke head component 1. (290 aa)
	ENSUPAP00010004389	annotation not available (180 aa)
	RIN2	Ras and Rab interactor 2. (864 aa)
	ENSUPAP00010005186	annotation not available (109 aa)
	MORN1	MORN repeat containing 1. (460 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (710 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
	MORN3	MORN repeat containing 3. (241 aa)
	DENND6B	DENN domain containing 6B. (585 aa)
	TRAPPC9	Trafficking protein particle complex 9. (1138 aa)
	ENSUPAP00010007856	annotation not available (853 aa)
	DENND4C	DENN domain containing 4C. (1957 aa)
	DENND3	DENN domain containing 3. (1337 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	ENSUPAP00010008438	annotation not available (464 aa)
	TRAPPC4	Trafficking protein particle complex 4. (219 aa)
	GAREM2	GRB2 associated regulator of MAPK1 subtype 2. (868 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	ENSUPAP00010009972	annotation not available (217 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	RAB14	RAB14, member RAS oncogene family. (215 aa)
	MORN5	MORN repeat containing 5. (171 aa)
	RIN1	Ras and Rab interactor 1. (760 aa)
	RAB1B	RAB1B, member RAS oncogene family. (201 aa)
	MON1B	MON1 homolog B, secretory trafficking associated. (552 aa)
	RINL	Ras and Rab interactor like. (562 aa)
	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2. (1345 aa)
	ANKRD27	Ankyrin repeat domain 27. (1054 aa)
	JPH4	Junctophilin 4. (628 aa)
	RAB1A	RAB1A, member RAS oncogene family. (205 aa)
	GDI1	GDP dissociation inhibitor 1. (447 aa)
	RAB12	RAB12, member RAS oncogene family. (338 aa)
	ENSUPAP00010015026	annotation not available (129 aa)
	ENSUPAP00010015404	annotation not available (206 aa)
	GAREM1	GRB2 associated regulator of MAPK1 subtype 1. (876 aa)
	TRAPPC8	Trafficking protein particle complex 8. (1463 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (443 aa)
	DENND1A	DENN domain containing 1A. (1038 aa)
	ANKMY1	Ankyrin repeat and MYND domain containing 1. (1016 aa)
	ENSUPAP00010030285	annotation not available (76 aa)
	DENND1C	DENN domain containing 1C. (765 aa)
	RAB21	RAB21, member RAS oncogene family. (221 aa)
	Rab3ip	RAB3A interacting protein. (459 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1010 aa)
	LOC113197309	Myotubularin-related protein 13-like. (394 aa)
	DENND5A	DENN domain containing 5A. (1288 aa)
	DENND2B	DENN domain containing 2B. (1161 aa)
	MON1A	MON1 homolog A, secretory trafficking associated. (571 aa)
	ENSUPAP00010028640	annotation not available (960 aa)
	AKT2	AKT serine/threonine kinase 2. (501 aa)
	DENND2C	DENN domain containing 2C. (934 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1036 aa)
	TRAPPC6B	Trafficking protein particle complex 6B. (158 aa)
	TRAPPC6A	Trafficking protein particle complex 6A. (159 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	RAB6B	RAB6B, member RAS oncogene family. (208 aa)
	ENSUPAP00010027028	annotation not available (106 aa)
	TRAPPC12	Trafficking protein particle complex 12. (789 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	TRAPPC13	Trafficking protein particle complex 13. (417 aa)
	CHM	CHM Rab escort protein. (648 aa)
	Rabgef1	RAB guanine nucleotide exchange factor 1. (492 aa)
	ENSUPAP00010001449	annotation not available (64 aa)
	DENND4A	DENN domain containing 4A. (1916 aa)
	ENSUPAP00010001346	annotation not available (58 aa)
	JPH2	Junctophilin 2. (694 aa)
	TRAPPC3L	Trafficking protein particle complex 3 like. (181 aa)
	GDI2	GDP dissociation inhibitor 2. (445 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	Trappc2	Trafficking protein particle complex 2. (133 aa)
	TRAPPC11	Trafficking protein particle complex 11. (1132 aa)

Your Current Organism:

Urocitellus parryii

NCBI taxonomy Id: 9999
Other names: Arctic ground squirrel, Citellus parryii, Spermophilus parryi, Spermophilus parryii, U. parryii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSUPAP00010023561	ENSUPAP00010028541	AKT serine/threonine kinase 1.	AKT serine/threonine kinase 2.	0.967
AKT1	AKT3	ENSUPAP00010023561	ENSUPAP00010023282	AKT serine/threonine kinase 1.	AKT serine/threonine kinase 3.	0.898
AKT1	YWHAE	ENSUPAP00010023561	ENSUPAP00010023047	AKT serine/threonine kinase 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon.	0.574
AKT2	AKT1	ENSUPAP00010028541	ENSUPAP00010023561	AKT serine/threonine kinase 2.	AKT serine/threonine kinase 1.	0.967
AKT2	AKT3	ENSUPAP00010028541	ENSUPAP00010023282	AKT serine/threonine kinase 2.	AKT serine/threonine kinase 3.	0.879
AKT2	YWHAE	ENSUPAP00010028541	ENSUPAP00010023047	AKT serine/threonine kinase 2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon.	0.574
AKT3	AKT1	ENSUPAP00010023282	ENSUPAP00010023561	AKT serine/threonine kinase 3.	AKT serine/threonine kinase 1.	0.898
AKT3	AKT2	ENSUPAP00010023282	ENSUPAP00010028541	AKT serine/threonine kinase 3.	AKT serine/threonine kinase 2.	0.879
AKT3	YWHAE	ENSUPAP00010023282	ENSUPAP00010023047	AKT serine/threonine kinase 3.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon.	0.574
ALS2	ALS2CL	ENSUPAP00010017891	ENSUPAP00010020232	Alsin Rho guanine nucleotide exchange factor ALS2.	ALS2 C-terminal like.	0.701
ALS2	ANKRD27	ENSUPAP00010017891	ENSUPAP00010012580	Alsin Rho guanine nucleotide exchange factor ALS2.	Ankyrin repeat domain 27.	0.764
ALS2	ENSUPAP00010001449	ENSUPAP00010017891	ENSUPAP00010001449	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.873
ALS2	ENSUPAP00010004389	ENSUPAP00010017891	ENSUPAP00010004389	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.650
ALS2	ENSUPAP00010009972	ENSUPAP00010017891	ENSUPAP00010009972	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.524
ALS2	ENSUPAP00010020560	ENSUPAP00010017891	ENSUPAP00010020560	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.524
ALS2	ENSUPAP00010027028	ENSUPAP00010017891	ENSUPAP00010027028	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.463
ALS2	ENSUPAP00010028640	ENSUPAP00010017891	ENSUPAP00010028640	Alsin Rho guanine nucleotide exchange factor ALS2.	annotation not available	0.715
ALS2	GAPVD1	ENSUPAP00010017891	ENSUPAP00010017115	Alsin Rho guanine nucleotide exchange factor ALS2.	GTPase activating protein and VPS9 domains 1.	0.841
ALS2	GDI1	ENSUPAP00010017891	ENSUPAP00010013722	Alsin Rho guanine nucleotide exchange factor ALS2.	GDP dissociation inhibitor 1.	0.650
ALS2	GDI2	ENSUPAP00010017891	ENSUPAP00010000052	Alsin Rho guanine nucleotide exchange factor ALS2.	GDP dissociation inhibitor 2.	0.650