Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tag
Unannotated protein. (184 aa)
Predicted Functional Partners:
polA
Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
0.584
Your Current Organism:
Leptospira alexanderi
NCBI taxonomy Id: 100053 Other names: ATCC 700520, L. alexanderi, Leptospira genomosp. 2, Leptospira genomospecies 2, Leptospira genospecies 2, strain L 60
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
polA
tag
GCA_002009845_01212
GCA_002009845_03137
Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
Unannotated protein.
0.584
tag
polA
GCA_002009845_03137
GCA_002009845_01212
Unannotated protein.
Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
0.584
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: