A0A1Y2WK78 protein (Daldinia sp. EC12) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

A0A1Y2WK78

SEC7 domain-containing protein. (1857 aa)

Predicted Functional Partners:

A0A1Y2XHC7

0.944

A0A1Y2WWT7

0.885

A0A1Y2WMS2

0.802

A0A1Y2X270

0.775

A0A1Y2XAS0

0.775

A0A1Y2WKI6

0.701

K445DRAFT_6949

0.652

K445DRAFT_7123

0.652

K445DRAFT_7287

0.621

A0A1Y2WYM8

0.605

Your Current Organism:

Daldinia sp. EC12

NCBI taxonomy Id: 1001832
Other names: D. sp. EC12

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y2WK78	A0A1Y2WKI6	A0A1Y2WK78	A0A1Y2WKI6	SEC7 domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.701
A0A1Y2WK78	A0A1Y2WMS2	A0A1Y2WK78	A0A1Y2WMS2	SEC7 domain-containing protein.	SEC7 domain-containing protein.	0.802
A0A1Y2WK78	A0A1Y2WWT7	A0A1Y2WK78	A0A1Y2WWT7	SEC7 domain-containing protein.	SEC7 domain-containing protein.	0.885
A0A1Y2WK78	A0A1Y2WYM8	A0A1Y2WK78	A0A1Y2WYM8	SEC7 domain-containing protein.	Uncharacterized protein.	0.605
A0A1Y2WK78	A0A1Y2X270	A0A1Y2WK78	A0A1Y2X270	SEC7 domain-containing protein.	Uncharacterized protein.	0.775
A0A1Y2WK78	A0A1Y2XAS0	A0A1Y2WK78	A0A1Y2XAS0	SEC7 domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.775
A0A1Y2WK78	A0A1Y2XHC7	A0A1Y2WK78	A0A1Y2XHC7	SEC7 domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.944
A0A1Y2WK78	K445DRAFT_6949	A0A1Y2WK78	A0A1Y2XF42	SEC7 domain-containing protein.	Uncharacterized protein.	0.652
A0A1Y2WK78	K445DRAFT_7123	A0A1Y2WK78	A0A1Y2XGI4	SEC7 domain-containing protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.652
A0A1Y2WK78	K445DRAFT_7287	A0A1Y2WK78	A0A1Y2XGW3	SEC7 domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.621
A0A1Y2WKI6	A0A1Y2WK78	A0A1Y2WKI6	A0A1Y2WK78	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	SEC7 domain-containing protein.	0.701
A0A1Y2WKI6	A0A1Y2WMS2	A0A1Y2WKI6	A0A1Y2WMS2	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	SEC7 domain-containing protein.	0.689
A0A1Y2WKI6	A0A1Y2WWT7	A0A1Y2WKI6	A0A1Y2WWT7	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	SEC7 domain-containing protein.	0.793
A0A1Y2WKI6	A0A1Y2WYM8	A0A1Y2WKI6	A0A1Y2WYM8	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.600
A0A1Y2WKI6	A0A1Y2X270	A0A1Y2WKI6	A0A1Y2X270	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.809
A0A1Y2WKI6	A0A1Y2XAS0	A0A1Y2WKI6	A0A1Y2XAS0	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.825
A0A1Y2WKI6	K445DRAFT_7287	A0A1Y2WKI6	A0A1Y2XGW3	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.679
A0A1Y2WMS2	A0A1Y2WK78	A0A1Y2WMS2	A0A1Y2WK78	SEC7 domain-containing protein.	SEC7 domain-containing protein.	0.802
A0A1Y2WMS2	A0A1Y2WKI6	A0A1Y2WMS2	A0A1Y2WKI6	SEC7 domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.689
A0A1Y2WMS2	A0A1Y2WWT7	A0A1Y2WMS2	A0A1Y2WWT7	SEC7 domain-containing protein.	SEC7 domain-containing protein.	0.856

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Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.643

expected number of edges:

14

PPI enrichment p-value:

0.0389

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019439

Aromatic compound catabolic process

8 of 56

1.57

2.65

7.00e-09

GO:0009056

Catabolic process

9 of 193

1.09

1.28

9.89e-07

GO:0042537

Benzene-containing compound metabolic process

3 of 10

1.89

1.25

0.0034

GO:0019619

3,4-dihydroxybenzoate catabolic process

2 of 3

2.24

0.82

0.0312

GO:0044282

Small molecule catabolic process

4 of 92

1.06

0.57

0.0371

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051213

Dioxygenase activity

4 of 13

1.91

1.83

0.00016

GO:0005506

Iron ion binding

4 of 13

1.91

1.83

0.00016

GO:0008199

Ferric iron binding

2 of 3

2.24

0.97

0.0160

GO:0004497

Monooxygenase activity

3 of 20

1.59

0.95

0.0106

GO:0016702

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

2 of 5

2.02

0.83

0.0278

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1699

Mixed, incl. Degradation of aromatic compounds, and Coenzyme A transferase

4 of 27

1.59

1.21

0.0022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01220

Degradation of aromatic compounds

5 of 30

1.64

2.02

1.07e-05

map00362

Benzoate degradation

5 of 31

1.62

2.0

1.07e-05

map00643

Styrene degradation

2 of 4

2.12

1.17

0.0061

map00361

Chlorocyclohexane and chlorobenzene degradation

2 of 5

2.02

1.13

0.0069

map00622

Xylene degradation

2 of 14

1.57

0.74

0.0321

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0223

Dioxygenase

3 of 8

1.99

1.47

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00775

Dioxygenase

2 of 2

2.42

0.8

0.0349

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 2

2.42

0.8

0.0349

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