A0A1Y2WKZ7 protein (Daldinia sp. EC12) - STRING interaction network

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Predicted Interactions

gene neighborhood

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A0A1Y2WKZ7

Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1055 aa)

Predicted Functional Partners:

A0A1Y2WUT6

0.601

A0A1Y2WM91

0.592

A0A1Y2WKG1

0.585

A0A1Y2X551

0.581

ADK2

0.581

A0A1Y2X4A6

0.575

A0A1Y2WY06

0.563

A0A1Y2WRD9

0.506

A0A1Y2X2H9

0.494

A0A1Y2X474

0.494

Your Current Organism:

Daldinia sp. EC12

NCBI taxonomy Id: 1001832
Other names: D. sp. EC12

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y2WKG1	A0A1Y2WKZ7	A0A1Y2WKG1	A0A1Y2WKZ7	Uncharacterized protein.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.585
A0A1Y2WKG1	A0A1Y2X551	A0A1Y2WKG1	A0A1Y2X551	Uncharacterized protein.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.424
A0A1Y2WKG1	ADK2	A0A1Y2WKG1	A0A1Y2XB69	Uncharacterized protein.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.503
A0A1Y2WKZ7	A0A1Y2WKG1	A0A1Y2WKZ7	A0A1Y2WKG1	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Uncharacterized protein.	0.585
A0A1Y2WKZ7	A0A1Y2WM91	A0A1Y2WKZ7	A0A1Y2WM91	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.592
A0A1Y2WKZ7	A0A1Y2WRD9	A0A1Y2WKZ7	A0A1Y2WRD9	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Uncharacterized protein.	0.506
A0A1Y2WKZ7	A0A1Y2WUT6	A0A1Y2WKZ7	A0A1Y2WUT6	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	PPM-type phosphatase domain-containing protein.	0.601
A0A1Y2WKZ7	A0A1Y2WY06	A0A1Y2WKZ7	A0A1Y2WY06	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Uncharacterized protein.	0.563
A0A1Y2WKZ7	A0A1Y2X2H9	A0A1Y2WKZ7	A0A1Y2X2H9	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	SWIRM domain-containing protein.	0.494
A0A1Y2WKZ7	A0A1Y2X474	A0A1Y2WKZ7	A0A1Y2X474	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Uncharacterized protein; Belongs to the CDC50/LEM3 family.	0.494
A0A1Y2WKZ7	A0A1Y2X4A6	A0A1Y2WKZ7	A0A1Y2X4A6	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.575
A0A1Y2WKZ7	A0A1Y2X551	A0A1Y2WKZ7	A0A1Y2X551	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.581
A0A1Y2WKZ7	ADK2	A0A1Y2WKZ7	A0A1Y2XB69	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.581
A0A1Y2WM91	A0A1Y2WKZ7	A0A1Y2WM91	A0A1Y2WKZ7	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.592
A0A1Y2WM91	A0A1Y2X551	A0A1Y2WM91	A0A1Y2X551	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.796
A0A1Y2WM91	ADK2	A0A1Y2WM91	A0A1Y2XB69	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.796
A0A1Y2WRD9	A0A1Y2WKZ7	A0A1Y2WRD9	A0A1Y2WKZ7	Uncharacterized protein.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.506
A0A1Y2WRD9	A0A1Y2X551	A0A1Y2WRD9	A0A1Y2X551	Uncharacterized protein.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.424
A0A1Y2WRD9	ADK2	A0A1Y2WRD9	A0A1Y2XB69	Uncharacterized protein.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.424
A0A1Y2WUT6	A0A1Y2WKZ7	A0A1Y2WUT6	A0A1Y2WKZ7	PPM-type phosphatase domain-containing protein.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.601

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.859

expected number of edges:

11

PPI enrichment p-value:

9.79e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

8 of 16

2.86

8.97

4.64e-18

GO:0000122

Negative regulation of transcription by RNA polymerase II

4 of 52

2.04

2.52

5.97e-06

GO:0006325

Chromatin organization

6 of 217

1.6

2.31

5.17e-07

GO:0006355

Regulation of transcription, DNA-templated

10 of 711

1.31

2.1

2.39e-10

GO:0061188

Negative regulation of ribosomal DNA heterochromatin assembly

2 of 2

3.16

2.01

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035064

Methylated histone binding

3 of 12

2.56

2.01

0.00019

GO:0003714

Transcription corepressor activity

3 of 21

2.31

1.88

0.00028

GO:0004407

Histone deacetylase activity

2 of 8

2.56

1.2

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070822

Sin3-type complex

6 of 12

2.86

6.59

3.35e-13

GO:0033698

Rpd3L complex

4 of 6

2.98

4.41

7.53e-09

GO:0005654

Nucleoplasm

7 of 239

1.62

2.73

1.24e-08

GO:0032221

Rpd3S/Clr6-CII complex

2 of 3

2.98

1.98

0.00026

GO:0035267

NuA4 histone acetyltransferase complex

2 of 16

2.25

1.38

0.0026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1510

Histone deacetylation, and Rpd3L-Expanded complex

10 of 12

3.08

13.17

6.06e-26

CL:1512

Histone deacetylation

5 of 6

3.08

5.87

1.48e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04139

Mitophagy - yeast

3 of 56

1.89

1.45

0.0012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

3 of 10

2.63

2.25

6.82e-05

MAP-9707564

Cytoprotection by HMOX1

3 of 28

2.19

1.71

0.00053

MAP-4839726

Chromatin organization

4 of 124

1.67

1.48

0.00053

MAP-3247509

Chromatin modifying enzymes

4 of 124

1.67

1.48

0.00053

MAP-212436

Generic Transcription Pathway

5 of 350

1.31

1.2

0.00053

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070822

Sin3-type complex

11 of 19

2.92

14.01

1.42e-28

GOCC:0033698

Rpd3L complex

6 of 9

2.98

7.36

1.53e-14

GOCC:0070210

Rpd3L-Expanded complex

3 of 6

2.86

3.21

1.24e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 349

1.22

0.73

0.0173

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02671

Paired amphipathic helix repeat

2 of 2

3.16

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039774

Transcriptional regulatory protein Sin3-like

2 of 2

3.16

1.16

0.0080

IPR036600

Paired amphipathic helix superfamily

2 of 2

3.16

1.16

0.0080

IPR003822

Paired amphipathic helix

2 of 2

3.16

1.16

0.0080

IPR019787

Zinc finger, PHD-finger

2 of 15

2.28

0.73

0.0453

IPR019786

Zinc finger, PHD-type, conserved site

2 of 16

2.25

0.73

0.0453

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00249

PHD zinc finger

2 of 23

2.1

0.73

0.0433

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