A0A1Y2WYK7 protein (Daldinia sp. EC12) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A1Y2WYK7

TPR_REGION domain-containing protein. (873 aa)

Predicted Functional Partners:

A0A1Y2X9L7

0.900

A0A1Y2XBN9

0.900

A0A1Y2XEK1

0.900

A0A1Y2WY97

0.851

A0A1Y2WU61

0.806

A0A1Y2WTE9

0.785

A0A1Y2X8B7

0.730

A0A1Y2WRP1

0.705

A0A1Y2XF08

0.691

A0A1Y2XCQ9

0.689

Your Current Organism:

Daldinia sp. EC12

NCBI taxonomy Id: 1001832
Other names: D. sp. EC12

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2WRP1	A0A1Y2WU61	Uncharacterized protein.	Uncharacterized protein.	0.670
A0A1Y2WRP1	A0A1Y2WY97	Uncharacterized protein.	CS domain-containing protein.	0.991
A0A1Y2WRP1	A0A1Y2WYK7	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.705
A0A1Y2WRP1	A0A1Y2X8B7	Uncharacterized protein.	Uncharacterized protein.	0.747
A0A1Y2WRP1	A0A1Y2X9L7	Uncharacterized protein.	HATPase_c domain-containing protein.	0.983
A0A1Y2WRP1	A0A1Y2XBN9	Uncharacterized protein.	Flavin_Reduct domain-containing protein.	0.983
A0A1Y2WRP1	A0A1Y2XEK1	Uncharacterized protein.	Uncharacterized protein.	0.981
A0A1Y2WTE9	A0A1Y2WYK7	WD_REPEATS_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.785
A0A1Y2WU61	A0A1Y2WRP1	Uncharacterized protein.	Uncharacterized protein.	0.670
A0A1Y2WU61	A0A1Y2WY97	Uncharacterized protein.	CS domain-containing protein.	0.732
A0A1Y2WU61	A0A1Y2WYK7	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.806
A0A1Y2WU61	A0A1Y2X8B7	Uncharacterized protein.	Uncharacterized protein.	0.694
A0A1Y2WU61	A0A1Y2X9L7	Uncharacterized protein.	HATPase_c domain-containing protein.	0.890
A0A1Y2WU61	A0A1Y2XBN9	Uncharacterized protein.	Flavin_Reduct domain-containing protein.	0.890
A0A1Y2WU61	A0A1Y2XEK1	Uncharacterized protein.	Uncharacterized protein.	0.888
A0A1Y2WY97	A0A1Y2WRP1	CS domain-containing protein.	Uncharacterized protein.	0.991
A0A1Y2WY97	A0A1Y2WU61	CS domain-containing protein.	Uncharacterized protein.	0.732
A0A1Y2WY97	A0A1Y2WYK7	CS domain-containing protein.	TPR_REGION domain-containing protein.	0.851
A0A1Y2WY97	A0A1Y2X8B7	CS domain-containing protein.	Uncharacterized protein.	0.987
A0A1Y2WY97	A0A1Y2X9L7	CS domain-containing protein.	HATPase_c domain-containing protein.	0.979

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.88

expected number of edges:

11

PPI enrichment p-value:

9.52e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

5 of 10

2.28

3.42

1.46e-07

GO:0006006

Glucose metabolic process

3 of 11

2.02

1.88

0.00017

GO:0010133

Proline catabolic process to glutamate

3 of 13

1.95

1.77

0.00025

GO:0016310

Phosphorylation

7 of 148

1.26

1.59

1.30e-06

GO:1901575

Organic substance catabolic process

8 of 195

1.2

1.54

3.32e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3 of 21

1.74

0.89

0.0174

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26388970

(2015) High quality draft genomic sequence of Flavihumibacter solisilvae 3-3(T).

2 of 20

1.58

1.17

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1300

Pentose phosphate pathway, and Glycolysis

6 of 22

2.02

3.46

2.01e-08

CL:1305

Glycolysis

4 of 7

2.34

3.06

1.08e-06

CL:1230

Carbon metabolism, and Dehydrogenase, E1 component

7 of 57

1.67

2.8

2.01e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 53

1.81

4.37

1.18e-13

map01200

Carbon metabolism

7 of 101

1.42

2.12

7.53e-08

map00680

Methane metabolism

3 of 23

1.7

1.43

0.00084

map00410

beta-Alanine metabolism

2 of 5

2.19

1.39

0.0023

map00561

Glycerolipid metabolism

3 of 26

1.65

1.37

0.00098

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 8

2.38

4.01

1.09e-08

KW-0312

Gluconeogenesis

2 of 4

2.28

1.09

0.0095

KW-0413

Isomerase

3 of 68

1.23

0.59

0.0470

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00171

Aldehyde dehydrogenase family

3 of 14

1.91

1.16

0.0053

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016160

Aldehyde dehydrogenase, cysteine active site

3 of 8

2.16

1.31

0.0033

IPR016163

Aldehyde dehydrogenase, C-terminal

3 of 14

1.91

1.12

0.0067

IPR016162

Aldehyde dehydrogenase, N-terminal

3 of 14

1.91

1.12

0.0067

IPR015590

Aldehyde dehydrogenase domain

3 of 14

1.91

1.12

0.0067

IPR016161

Aldehyde/histidinol dehydrogenase

3 of 15

1.88

1.11

0.0067

(more ...)

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