STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A1Y2X572Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (698 aa)    
Predicted Functional Partners:
A0A1Y2WNQ3
Autophagy-related protein.
   
 0.998
A0A1Y2WVK4
Autophagy-related protein 3.
  
 
 0.998
A0A1Y2WU76
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
    
 0.988
A0A1Y2WL20
Zn(2)-C6 fungal-type domain-containing protein.
   
 0.983
A0A1Y2X9H4
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.981
A0A1Y2X0D2
HECT domain-containing protein.
    
 0.972
A0A1Y2XDY3
Lipase_3 domain-containing protein.
   
 
 0.969
A0A1Y2WZD8
Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
    
 0.932
A0A1Y2X4P6
Autophagy_act_C domain-containing protein.
   
 0.925
A0A1Y2WYP3
Uncharacterized protein.
    
 0.923
Your Current Organism:
Daldinia sp. EC12
NCBI taxonomy Id: 1001832
Other names: D. sp. EC12
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.