A0A1Y2X9X5 protein (Daldinia sp. EC12) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

A0A1Y2X9X5

Uncharacterized protein. (248 aa)

Predicted Functional Partners:

A0A1Y2X8N7

0.788

A0A1Y2WVQ0

0.671

A0A1Y2X2P8

0.655

A0A1Y2WL17

0.653

A0A1Y2X8P2

0.653

A0A1Y2XB80

0.623

A0A1Y2WWN2

0.597

A0A1Y2WYW4

0.597

A0A1Y2XCD5

0.596

A0A1Y2WWX3

0.571

Your Current Organism:

Daldinia sp. EC12

NCBI taxonomy Id: 1001832
Other names: D. sp. EC12

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2WL17	A0A1Y2WVQ0	Uncharacterized protein; Belongs to the GST superfamily.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.671
A0A1Y2WL17	A0A1Y2WWN2	Uncharacterized protein; Belongs to the GST superfamily.	RPOLD domain-containing protein.	0.597
A0A1Y2WL17	A0A1Y2WWX3	Uncharacterized protein; Belongs to the GST superfamily.	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.571
A0A1Y2WL17	A0A1Y2WYW4	Uncharacterized protein; Belongs to the GST superfamily.	RPOLD domain-containing protein.	0.597
A0A1Y2WL17	A0A1Y2X2P8	Uncharacterized protein; Belongs to the GST superfamily.	Uncharacterized protein.	0.655
A0A1Y2WL17	A0A1Y2X8N7	Uncharacterized protein; Belongs to the GST superfamily.	Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family.	0.788
A0A1Y2WL17	A0A1Y2X8P2	Uncharacterized protein; Belongs to the GST superfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.623
A0A1Y2WL17	A0A1Y2X9X5	Uncharacterized protein; Belongs to the GST superfamily.	Uncharacterized protein.	0.653
A0A1Y2WL17	A0A1Y2XCD5	Uncharacterized protein; Belongs to the GST superfamily.	Thioredoxin domain-containing protein.	0.820
A0A1Y2WVQ0	A0A1Y2WL17	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Uncharacterized protein; Belongs to the GST superfamily.	0.671
A0A1Y2WVQ0	A0A1Y2WWX3	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.466
A0A1Y2WVQ0	A0A1Y2X2P8	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Uncharacterized protein.	0.786
A0A1Y2WVQ0	A0A1Y2X8N7	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family.	0.996
A0A1Y2WVQ0	A0A1Y2X8P2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Uncharacterized protein; Belongs to the GST superfamily.	0.671
A0A1Y2WVQ0	A0A1Y2X9X5	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Uncharacterized protein.	0.671
A0A1Y2WWN2	A0A1Y2WL17	RPOLD domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.597
A0A1Y2WWN2	A0A1Y2WYW4	RPOLD domain-containing protein.	RPOLD domain-containing protein.	0.833
A0A1Y2WWN2	A0A1Y2X2P8	RPOLD domain-containing protein.	Uncharacterized protein.	0.486
A0A1Y2WWN2	A0A1Y2X8P2	RPOLD domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.597
A0A1Y2WWN2	A0A1Y2X9X5	RPOLD domain-containing protein.	Uncharacterized protein.	0.597

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.952

expected number of edges:

47

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045471

Response to ethanol

4 of 5

2.89

3.56

2.76e-07

GO:0006636

Unsaturated fatty acid biosynthetic process

4 of 7

2.75

3.46

3.61e-07

GO:0000001

Mitochondrion inheritance

4 of 13

2.48

3.09

1.30e-06

GO:0022900

Electron transport chain

4 of 62

1.8

1.76

0.00017

GO:0006366

Transcription by RNA polymerase II

4 of 94

1.62

1.43

0.00063

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004768

stearoyl-CoA 9-desaturase activity

4 of 4

2.99

3.91

6.68e-08

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 22

2.12

1.62

0.00073

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

4 of 12

2.51

3.18

9.10e-07

GO:0030176

Integral component of endoplasmic reticulum membrane

4 of 55

1.85

1.87

0.00011

GO:0005736

RNA polymerase I complex

2 of 11

2.25

1.22

0.0052

GO:0005666

RNA polymerase III complex

2 of 16

2.09

1.07

0.0094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11013

Fatty acid metabolism, and Very long-chain fatty acid biosynthetic process

4 of 12

2.51

2.99

2.13e-06

CL:11025

Fatty acid desaturase type 1, conserved site, and Fatty acid elongase activity

3 of 6

2.69

2.52

2.20e-05

CL:4140

RNA polymerase, and Transcription elongation factor complex

4 of 63

1.79

1.81

0.00012

CL:4155

RNA polymerase II, core complex

2 of 7

2.44

1.27

0.0045

CL:4217

RNA polymerase III complex

2 of 14

2.14

1.0

0.0132

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 37

2.02

2.43

9.02e-06

map01040

Biosynthesis of unsaturated fatty acids

4 of 94

1.62

1.63

0.00016

map01212

Fatty acid metabolism

4 of 152

1.41

1.26

0.00066

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

4 of 31

2.1

2.26

2.93e-05

MAP-113418

Formation of the Early Elongation Complex

4 of 31

2.1

2.26

2.93e-05

MAP-72086

mRNA Capping

4 of 33

2.07

2.25

2.93e-05

MAP-9018519

Estrogen-dependent gene expression

4 of 34

2.06

2.24

2.93e-05

MAP-75955

RNA Polymerase II Transcription Elongation

4 of 41

1.98

2.19

2.93e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005736

RNA polymerase I complex

2 of 8

2.39

0.82

0.0317

GOCC:0005665

RNA polymerase II, core complex

2 of 7

2.44

0.82

0.0317

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

3 of 61

1.68

0.76

0.0317

GOCC:0005783

Endoplasmic reticulum

4 of 287

1.13

0.61

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

6 of 116

1.7

2.6

2.05e-07

KW-0275

Fatty acid biosynthesis

3 of 10

2.47

2.51

1.84e-05

KW-0249

Electron transport

3 of 18

2.21

2.2

5.11e-05

KW-0240

DNA-directed RNA polymerase

3 of 26

2.05

2.03

8.74e-05

KW-0560

Oxidoreductase

6 of 438

1.12

1.14

7.61e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00487

Fatty acid desaturase

4 of 10

2.59

3.29

6.38e-07

PF00970

Oxidoreductase FAD-binding domain

2 of 9

2.33

0.85

0.0279

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018506

Cytochrome b5, heme-binding site

6 of 14

2.62

5.46

2.50e-11

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

6 of 26

2.35

4.67

2.91e-10

IPR001199

Cytochrome b5-like heme/steroid binding domain

6 of 27

2.33

4.65

2.91e-10

IPR015876

Acyl-CoA desaturase

4 of 4

2.99

4.09

3.10e-08

IPR005804

Fatty acid desaturase domain

4 of 10

2.59

3.42

3.53e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

6 of 27

2.33

4.89

7.96e-11

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