Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Znf263Zinc finger protein 263 isoform X1. (680 aa)    
Predicted Functional Partners:
Scand1
SCAN domain-containing protein 1.
    
   0.946
Sufu
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.873
Zfp397
Zinc finger protein 397 isoform X2.
    
 
 0.858
Zscan20
Zinc finger and SCAN domain-containing protein 20 isoform X1.
    
   0.848
Foxred1
FAD-dependent oxidoreductase domain-containing protein 1.
      
 0.836
Znf446
Zinc finger protein 446.
    
   0.821
Rpgrip1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1.
    
 0.708
Trim28
Transcription intermediary factor 1-beta.
    
 0.669
L3mbtl4
Lethal(3)malignant brain tumor-like protein 4.
    
 0.647
Nme8
Thioredoxin domain-containing protein 3 isoform X1.
    
 0.647
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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