Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Htra4Serine protease HTRA4. (483 aa)    
Predicted Functional Partners:
Gcm1
Chorion-specific transcription factor GCMa.
    
 
 0.944
Mapt
Microtubule-associated protein.
    
   0.859
Xiap
E3 ubiquitin-protein ligase XIAP isoform X1.
    
 
 0.856
Birc6
Baculoviral IAP repeat-containing protein 6.
    
 0.851
Armc8
Armadillo repeat-containing protein 8 isoform X2.
    
 
 0.812
Tnf
Tumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family.
    
 
 0.784
Psmd1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
    
 0.761
Pink1
Serine/threonine-protein kinase PINK1, mitochondrial.
    
 
 0.757
Psmd12
26S proteasome non-ATPase regulatory subunit 12.
    
 0.739
Psmd11
26S proteasome non-ATPase regulatory subunit 11.
    
 0.737
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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