STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pde6cPhosphodiesterase. (861 aa)    
Predicted Functional Partners:
Pde6g
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma.
   
 0.932
Adcy5
Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    
 0.917
Adcy6
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
    
 0.917
Adcy3
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
    
 0.917
Gnat2
Guanine nucleotide-binding protein G(T) subunit alpha-2.
   
 0.906
Nt5e
5'-nucleotidase; Belongs to the 5'-nucleotidase family.
     
 0.904
Pde6d
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
    
 0.903
Adcy1
Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    
 0.901
Npr2
Guanylate cyclase.
    
 0.901
Adcy8
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
    
 0.901
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.