STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Bak1Bcl-2 homologous antagonist/killer. (211 aa)    
Predicted Functional Partners:
Bcl2l1
Bcl-2-like protein 1 isoform X1.
    
0.997
Bcl2l11
Bcl-2-like protein 11 isoform X1.
    
 0.994
Bid
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
    
 0.992
Bcl2l2
Bcl-2-like protein 2.
    
0.989
Bcl2
Apoptosis regulator Bcl-2.
    
0.981
Trp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.976
Mcl1
Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1.
    
0.975
Bcl2a1
Bcl-2-related protein A1.
    
 
 0.950
Bax
Apoptosis regulator BAX.
    
 0.922
Bad
Bcl2-associated agonist of cell death isoform X1.
   
 0.919
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.