STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEW43529.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (620 aa)    
Predicted Functional Partners:
SEW36840.1
2-oxoisovalerate dehydrogenase E1 component.
 
 0.999
SEW43538.1
Pyruvate dehydrogenase E1 component beta subunit.
 0.996
SEW43545.1
Pyruvate dehydrogenase E1 component alpha subunit.
 
 0.994
SEW39688.1
Pyruvate dehydrogenase E1 component beta subunit.
 0.986
sucA
2-oxoglutarate dehydrogenase E1 component.
 
0.983
SEW39679.1
Pyruvate dehydrogenase E1 component alpha subunit.
 0.979
lpd-2
Dihydrolipoamide dehydrogenase.
 0.957
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.946
lpd
Dihydrolipoamide dehydrogenase.
 0.931
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.913
Your Current Organism:
Austwickia chelonae
NCBI taxonomy Id: 100225
Other names: A. chelonae, ATCC 51576, CCUG 47447, DSM 44178, Dermatophilus chelonae, JCM 9706, NBRC 105200, strain W16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.