STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0348SCF41.07, possible 2-hydroxyacid-family dehydrogenase, len: 339 aa. Similar to Mycobacterium leprae SW:SERA_MYCLE (EMBL; Z99263) D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (PGDH) MLCB637.25 (528 aa), fasta scores opt: 452 z-score: 525.4 E(): 6.5e-22 36.7% identity in 286 aa overlap and Pyrococcus abyssi TR:CAB49675 (EMBL; AJ248285) SERA-like protein (307 aa), fasta scores opt: 437 z-score: 511.6 E(): 3.8e-21 32.0% identity in 309 aa overlap. Contains a Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases. (339 aa)    
Predicted Functional Partners:
SCO0349
SCF41.08, possible oxidoreductase (putative secreted protein), len: 334 aa. Similar to Pseudomonas sp. TR:Q52472 (EMBL; D32042) L-fucose dehydrogenase (329 aa), fasta scores opt: 960 z-score: 1078.8 E(): 0 48.4% identity in 318 aa overlap.
 
    0.831
SCO0347
SCF41.06, possible racemase, len: 416 aa. Similar to Pseudomonas putida SW:MANR_PSEPU (EMBL; M19043) mandelate racemase (EC 5.1.2.2) (359 aa), fasta scores opt: 322 z-score: 326.6 E(): 7.7e-11 27.9% identity in 366 aa overlap. Contains a Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. This gene is duplicated on this cosmid and shares 74.3% identity, in 378 aa overlap, with the downstream gene, SCF41.17. Note the predicted protein product of SCF41.06 is 36 aa longer than that of SCF41.17.
 
     0.817
SCO0350
Conserved hypothetical protein; SCF41.09, unknown, len: 334 aa. Similar to several hypotheticals including: Rhizobium sp. SW:Y4MH_RHISN (EMBL; AE000085) hypothetical 33.9 KD protein Y4MH (297 aa), fasta scores opt: 262 z-score: 309.5 E(): 6.9e-10 23.8% identity in 303 aa overlap.
 
     0.803
SCO0351
Hypothetical protein SCF41.10; SCF41.10, unknown, len: 491 aa.
       0.773
SCO4366
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
 
 
 0.753
SCO0352
SCF41.11 possible solute-binding protein, len: 422 aa. Similar to many including: Streptomyces lividans TR:Q9Z492 (EMBL; AF043654) BxlE precursor (434 aa), fasta scores opt: 287 z-score: 311.3 E(): 5.5e-10 25.7% identity in 354 aa overlap. Contains a PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence.
 
     0.676
SCO0353
SCF41.12, possible binding-protein-dependent transport protein, len: 303 aa. Similar to many including: Streptomyces coelicolor TR:CAB41203 (EMBL; AL049661) putative binding protein dependent transport protein SCE134.05c (327 aa), fasta scores opt: 560 z-score: 661.2 E(): 1.8e-29 35.5% identity in 301 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains multiple potential membrane-spanning hydrophobic domains.
       0.613
SCO0354
SCF41.13, possible binding-protein-dependent transport protein, len: 280 aa, Similar to many e.g. Streptomyces coelicolor TR:O50501 (EMBL; AL009199) probable transmembrane transport protein SC7b7.04 (302 aa), fasta scores opt: 584 z-score: 670.3 E(): 5.5e-30 36.1% identity in 274 aa overlap. Contains multiple membrane spanning hydrophobic domains, a PS00402 Binding-protein-dependent transport systems inner membrane comp sign and a Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component.
       0.613
SCO0356
SCF41.15, probable oxidoreductase, len: 263 aa. Shares a high level of sequence similarity with Comamonas testosteroni TR:P94681 (EMBL:U32622) toluenesulfonate zinc-independent alcohol dehydrogenase (252 aa), fasta scores opt: 506 z-score: 549.4 E(): 3e-23 39.8% identity in 244 aa overlap and Streptomyces coelicolor TR:O88068 (EMBL:AL031541) putative dehydrogenase SCI35.33C (260 aa), fasta scores opt: 500 z-score: 542.8 E(): 7e-23 36.4% identity in 253 aa overlap. Contains a Pfam match to entry PF00106 adh_short, short chain dehydrogenase, Pfam match to entry PF00678 adh_short_C2, Shor [...]
 
 
   0.594
SCO2750
SCC57A.21c, hypothetical protein, len: 287 aa; similar to TR:CAC41509 (EMBL:AL591782) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMC04130, 274 aa; fasta scores: opt: 796 Z-score: 889.6 E(): 6.4e-42; 47.191% identity in 267 aa overlap.
 
     0.503
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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