STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0560Catalase/peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. (740 aa)    
Predicted Functional Partners:
SCO0561
SCF73.08c, furS, Fe regulatory protein, len: 151 aa; identical to TR:CAB38251 (EMBL:AJ132989) S. coelicolor Fe regulatory protein (151 aa), highly similar to e.g. FUR_MYCTU ferric uptake regulation protein (147 aa), fasta scores; opt: 613 z-score: 742.2 E(): 0, 64.8% identity in 142 aa overlap. Contains Pfam match to entry PF01475 FUR, Ferric uptake regulator family; Belongs to the Fur family.
     
 0.984
SCO2053
SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
     
 0.924
SCO1859
SCI39.06, probable aminotransferase, len: 339 aa; similar to SW:HIS8_ECOLI (EMBL:X03416) Escherichia coli histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC, 356 aa; fasta scores: opt: 351 Z-score: 375.7 bits: 78.0 E(): 2.4e-13; 29.450% identity in 309 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferase class-II and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
     
 0.905
SCO3944
Putative histidinol-phophate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
     
 0.905
SCO4645
SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
     
 0.905
SCO3645
Putative hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.
     
  0.900
SCO2633
Superoxide dismutase [Fe-Zn] (EC 1.15.1.1); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
    
 0.868
SCO1814
SCI28.08c, inhA, probable enoyl-(acyl-carrier-protein) reductase, len: 269 aa; similar to many e.g. SW:INHA_MYCSM enoyl-(acyl-carrier-protein) reductase involved from Mycobacterium smegmatis (269 aa) fasta scores; opt: 740, z-score: 852.1, E(): 0, (51.3% identity in 263 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase.
      
 0.848
SCO5032
SCK7.05c, ahpC, alkyl hydroperoxide reductase, len:184 aa; identical to previously seqeunced TR:Q9RN72 (EMBL:AF186371) Streptomyces coelicolor A3(2) AhpC, 184 aa. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family.
  
  
 0.828
SCO3962
SCD78.29c, pheA, prephenate dehydratase, len: 310 aa, similar to many eg. PHEA_AMYME (EMBL:L47666) prephenate dehydratase from Amycolatopsis methanolica (304 aa), fasta scores; opt: 821, z-score: 1164.7, E(): 0, 46.9% identity in 305 aa overlap. Contains PS00857 Prephenate dehydratase signature 1 and Pfam match to entry PF00800 PDT, Prephenate dehydratase, score 354.80, E-value 9.5e-103. Note: Can participate in the biosynthesis of Phenylalanine, Tyrosine and Tryptophan.
     
  0.800
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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