STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0717SCF42.27, possible integral membrane protein, len: 375 aa. Similar to several other membrane proteins from Streptomyces coelicolor e.g. TR:CAB56388(EMBL:AL118515) SCD17.11 (454 aa), fasta scores opt: 569 z-score: 648.9 E(): 9.3e-29 36.4% identity in 360 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (375 aa)    
Predicted Functional Partners:
SCO3284
SCE15.01, partial CDS, conserved hypothetical protein, len: >436aa; similar to C-terminal region of TR:CAA22732 (EMBL:AL035161) another conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 922, z-score: 1011.5, E(): 0, (39.5% identity in 425 aa overlap); SCE39.34, unknown, len: >307aa; similar to TR:E1370406 (EMBL:AL035161) conserved hypothetical protein from Streptomyces coelicolor (860 aa) fasta scores; opt: 254, z-score: 277.0, E(): 4e-08, (29.2% identity in 277 aa overlap) TR:O86875 (EMBL:U22894) hypothetical protein from Streptomyces lividans (54 [...]
 
 
 0.830
SCO7009
Conserved hypothetical protein; SC8F11.35c, unknown, len: 593 aa. Identical, apart from the very C-terminus, to Streptomyces lividans TR:O86875(EMBL:U22894) hypothetical 57.9 kd protein, AglX (547 aa), fasta scores opt: 3357 z-score: 3741.0 E(): 0 98.8% identity in 519 aa overlap. Also highly similar to several Streptomyces coelicolor hypothetical proteins e.g. TR:CAB61537(EMBL:AL133171) SCF81.26 (835 aa), fasta scores opt: 1133 z-score: 1260.6 E(): 0 43.0% identity in 575 aa overlap.
 
   0.825
SCO2560
Conserved hypothetical protein; SCC77.27c, unknown, len: 792 aa. Weakly similar to Streptomyces coelicolor TR:O86807 (EMBL:AL031031) putative regulatory protein SC7C7.02C (916 aa), fasta scores opt: 447 z-score: 376.3 E(): 1.4e-13 34.1% identity in 954 aa overlap. The N-terminus is also similar Streptomyces coelicolor TR:Q53897(EMBL:X60316) OrfA within the AbaA pleiotropic regulatory locus for antibiotic production (192 aa), fasta scores opt: 248 z-score: 220.6 E(): 6.7e-05 37.1% identity in 178 aa overlap.
  
   0.824
SCO7220
Conserved hypothetical protein SC2H12.19c; SC2H12.19c, unknown, len: 667 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:Q9RJC6(EMBL:AL133171) SCF81.26 (835 aa), opt: 1057 z-score: 1135.5 E():0 38.6% identity in 643 aa overlap.
  
     0.771
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
  
   0.770
SCO0451
SCF51A.29c, unknown, len: 284 aa. Similar to the C-terminus of many hypothetical proteins e.g. Mycobacterium tuberculosis SW:Y07S_MYCTU (EMBL; Z75555) hypothetical 69.5 KD protein CY02B10.28C (653 aa), fasta scores opt: 390 z-score: 451.1 E(): 9.1e-18 33.5% identity in 263 aa overlap. In addition to Bacillus subtilis SW:RSBU_BACSU (EMBL; L35574) sigma factor SibG regulation protein RsbU (335 aa), fasta scores opt: 206 z-score: 243.6 E(): 3.3e-06 24.3% identity in 185 aa overlap.
  
     0.769
SCO3971
SCBAC25E3.08c, conserved hypothetical protein, len: 477 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RJ90 (EMBL:AL132973) hypothetical protein SCF91.35 (884 aa) fasta scores; opt: 458, Z-score: 470.1, 31.210% identity (34.507% ungapped) in 471 aa overlap.
  
     0.767
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
  
   0.686
SCO0716
SCF42.26, possible glycosyl hydrolase (putative secreted protein), len: 400 aa. Similar to several including: Arthrobacter sp. (strain YCWD3) SW:E13B_ARTSP(EMBL:D23668) glucan endo-1,3-beta-glucosidase precursor (EC 3.2.1.39) (548 aa), fasta scores opt: 425 z-score: 452.8 E(): 7.8e-18 34.5% identity in 414 aa overlap and Streptomyces matensis TR:Q9Z4I2(EMBL:AB019428) laminaripentaose-producing beta-1,3-guluase (lphase) precursor (401 aa), fasta scores opt: 477 z-score: 509.6 E(): 5.4e-21 38.7% identity in 413 aa overlap. Contains a possible N-terminal signal sequence.
       0.625
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
  
   0.616
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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