node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0985 | SCO1294 | gene:17758568 | gene:17758877 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | 0.976 |
SCO0985 | SCO1476 | gene:17758568 | gene:17759062 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.987 |
SCO0985 | SCO1657 | gene:17758568 | gene:17759250 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.996 |
SCO0985 | SCO2103 | gene:17758568 | gene:17759701 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | SC4A10.36c, metF, 5,10-methylenetetrahydrofolate reductase, len: 307 aa; identical to SW:METF_STRLI (EMBL:AJ001630), MetF, Streptomyces lividans 5,10-methylenetetrahydrofolate reductase (307 aa), apart from substitution of Arg41 for Lys41 in S.coelicolor, fasta scores; opt: 2015 z-score: 2364.3 E(): 0, 99.7% identity in 307 aa overlap. | 0.958 |
SCO0985 | SCO3023 | gene:17758568 | gene:17760638 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.984 |
SCO0985 | SCO3077 | gene:17758568 | gene:17760692 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | SCE25.18, probable cystathionine beta-synthase, len: 461 aa; highly similar to TR:O53425 (EMBL:AL021897) Mycobacterium tuberculosis cystathionine beta-synthase CysM, 464 aa; fasta scores: opt: 2025 z-score: 2184.8 E(): 0; 67.6% identity in 454 aa overlap, to TR:Q9YHU3 (EMBL:AF090120) Fugu rubripe cystathionine beta-synthase, 585 aa; fasta scores: opt: 1087 z-score: 1173.5 E(): 0; 39.6% identity in 465 aa overlap and to TR:CAB50991 (EMBL:AL096852) Streptomyces coelicolor putative cysteine synthase SCE19A.10c, 316 aa; fasta scores: opt: 558 z-score: 540.6 E(): 1.4e-24; 40.3% identity in [...] | 0.933 |
SCO0985 | SCO3920 | gene:17758568 | gene:17761547 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] | 0.977 |
SCO0985 | SCO4958 | gene:17758568 | gene:17762607 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 2SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. | 0.977 |
SCO0985 | SCO5356 | gene:17758568 | gene:17763008 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.930 |
SCO0985 | SCO6137 | gene:17758568 | gene:17763796 | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | SC1A9.01c, possible transferase, partial CDS, len: 219 aa, similar to TR:O53185 (EMBL:AL021246) a proposed transferase from Mycobacterium tuberculosis (302 aa), fasta scores: opt: 764, z-score: 1097.3, E(): 0, (62.1% identity in 203 aa overlap (302 aa). Also weakly similar to several methyltransferases eg. METH_ECOLI (EMBL:X16584)5-methyltetrahydrofolate-homocysteine methyltransferase (1226 aa), fasta scores; opt:160, z-score: 234.8, E(): 8.4e-06, (30.0% identity in 220 aa overlap); SC9B2.24c, partial CDS, possible transferase, len: 113aa; constitutes the C-terminal end of SC1A9.01c (E [...] | 0.920 |
SCO1294 | SCO0985 | gene:17758877 | gene:17758568 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.976 |
SCO1294 | SCO1476 | gene:17758877 | gene:17759062 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.946 |
SCO1294 | SCO1657 | gene:17758877 | gene:17759250 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.985 |
SCO1294 | SCO2103 | gene:17758877 | gene:17759701 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | SC4A10.36c, metF, 5,10-methylenetetrahydrofolate reductase, len: 307 aa; identical to SW:METF_STRLI (EMBL:AJ001630), MetF, Streptomyces lividans 5,10-methylenetetrahydrofolate reductase (307 aa), apart from substitution of Arg41 for Lys41 in S.coelicolor, fasta scores; opt: 2015 z-score: 2364.3 E(): 0, 99.7% identity in 307 aa overlap. | 0.798 |
SCO1294 | SCO3077 | gene:17758877 | gene:17760692 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | SCE25.18, probable cystathionine beta-synthase, len: 461 aa; highly similar to TR:O53425 (EMBL:AL021897) Mycobacterium tuberculosis cystathionine beta-synthase CysM, 464 aa; fasta scores: opt: 2025 z-score: 2184.8 E(): 0; 67.6% identity in 454 aa overlap, to TR:Q9YHU3 (EMBL:AF090120) Fugu rubripe cystathionine beta-synthase, 585 aa; fasta scores: opt: 1087 z-score: 1173.5 E(): 0; 39.6% identity in 465 aa overlap and to TR:CAB50991 (EMBL:AL096852) Streptomyces coelicolor putative cysteine synthase SCE19A.10c, 316 aa; fasta scores: opt: 558 z-score: 540.6 E(): 1.4e-24; 40.3% identity in [...] | 0.948 |
SCO1294 | SCO3920 | gene:17758877 | gene:17761547 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] | 0.926 |
SCO1294 | SCO4958 | gene:17758877 | gene:17762607 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | 2SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. | 0.843 |
SCO1294 | SCO6137 | gene:17758877 | gene:17763796 | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | SC1A9.01c, possible transferase, partial CDS, len: 219 aa, similar to TR:O53185 (EMBL:AL021246) a proposed transferase from Mycobacterium tuberculosis (302 aa), fasta scores: opt: 764, z-score: 1097.3, E(): 0, (62.1% identity in 203 aa overlap (302 aa). Also weakly similar to several methyltransferases eg. METH_ECOLI (EMBL:X16584)5-methyltetrahydrofolate-homocysteine methyltransferase (1226 aa), fasta scores; opt:160, z-score: 234.8, E(): 8.4e-06, (30.0% identity in 220 aa overlap); SC9B2.24c, partial CDS, possible transferase, len: 113aa; constitutes the C-terminal end of SC1A9.01c (E [...] | 0.971 |
SCO1476 | SCO0985 | gene:17759062 | gene:17758568 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.987 |
SCO1476 | SCO1294 | gene:17759062 | gene:17758877 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. | 0.946 |