STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1187SCG11A.18, celB, secreted cellulase B precursor, len: 381 aa; identical to TR:Q54331 (EMBL:U04629) Streptomyces lividans cellulase precursor, celB, 381 aa and similar to SW:GUX_CELFI (EMBL:M15824) Cellulomonas fimi exoglucanase/xylanase precursor [includes: exoglucanase (EC 3.2.1.91) (exocellobiohydrolase) (1,4-beta-cellobiohydrolase) (beta-1,4- glycanase Cex); endo-1,4-beta-xylanase B (EC 3.2.1.8) (xylanase B) Cex or XynB, 484 aa; fasta scores: opt: 422 z-score: 450.5 E(): 1e-17; 48.8% identity in 123 aa overlap. Contains two matches to Pfam entries PF01670 Glyco_hydro_12, Glycosyl hy [...] (381 aa)    
Predicted Functional Partners:
SCO1110
2SCG38.03, probable secreted lyase, len: 266 aa; similar to TR:Q04701 (EMBL:M94691) Fusarium solani pectate lyase A precursor (EC 4.2.2.2) PelA, 242 aa; fasta scores: opt: 605 z-score: 664.1 E(): 1.5e-29; 43.6% identity in 236 aa overlap. Contains possible N-terminal region signal peptide sequence.
 
 
 0.781
SCO5932
Arabinofuranosidase; Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well (By similarity); Belongs to the glycosyl hydr olase 62 family.
 
     0.740
SCO2292
SCC75A.38, xlnB, secreted endo-1,4-beta-xylanase B (xylanase B), len: 335 aa. Almost identical to Streptomyces lividans SW:XYNB_STRLI(EMBL:M64552) endo-1,4-beta-xylanase B precursor (xylanase B) (EC 3.2.1.8) (334 aa), fasta scores opt: 2266 z-score: 2249.3 E():0 98.2% identity in 335 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52919 (EMBL:AL109949) endo-1,4-beta-xylanase, XlnC (241 aa), fasta scores opt: 1087 z-score: 970.6 E():0 71.9% identity in 224 aa overlap and to the adjoining CDS on this cosmid, AxeA, (335 aa), fasta scores opt: 652 z-score: 585.8 E(): 2.9e-27 56.2 [...]
 
     0.732
SCO0105
SCJ11.34c, xlnC, endo-1,4-beta-xylanase (putative secreted protein), len: 241 aa; highly similar to many endo-1,4-beta-xylanases e.g. SW:XYNC_STRLI from Streptomyces lividans (240 aa) fasta scores; opt: 1605, z-score: 1785.1, E(): 0, (97.9% identity in 241 aa overlap) and SW:XYNA_BACSU from Bacillus subtilis (213 aa) fasta scores; opt: 813, z-score: 910.7, E(): 0, (58.8% identity in 221 aa overlap). Contains Pfam match to entry PF00457 Glyco_hydro_11, Glycosyl hydrolases family 11 and Prosite matches to PS00777 Glycosyl hydrolases family 11 active site signature 2 and PS00776 Glycosyl [...]
 
     0.729
SCO6234
SC2H4.16, manA, probable secreted beta-mannosidase, len: 384 aa; 94.5% identical to MANA_STRLI mannan endo-1,4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5), score 104.70, E-value 1.8e-27.
  
     0.727
SCO5931
SC10A5.36c, xlnA, xylanase A precursor, partial CDS, len >383 aa; overlaps and extends ORF from neighbouring cosmid SC7H1.01c; almost identical to XYNA_STRLI P26514 endo- 1,4-beta-xylanase a precursor (477 aa) (99.2% identity in 383 aa overlap). Conatains PS00591 Glycosyl hydrolases famil y 10 active site and Pfam match to entry glycosyl_hydro3 PF 00331, Glycosyl hydrolases family 10, score 183.41. Also si milar in part to S. coelicolor SC7H1.02, abfB, arabinofuran osidase (E(): 1.4e-35, 58.4% identity in 149 aa overlap); SC7H1.01c, xlnA, xylanase A precursor, partial CDS, len >147 aa; [...]
   
 0.715
SCO2229
SC10B7.24c, malG, putative maltose permease, len: 303 aa; identical to previously sequenced TR:P72399 (EMBL:Y07706) Streptomyces coelicolor putative maltose permease MalG, 302 aa and similar to SW:MALG_ECOLI (EMBL:X02871) Escherichia coli maltose transport system permease protein MalG, 296 aa; fasta scores: opt: 476 z-score: 570.0 E(): 2.3e-24; 34.1% identity in 293 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane [...]
   
  
 0.670
SCO1188
SCG11A.19, celS2, secreted cellulose binding protein len: 364 aa; highly similar to TR:AAD27623 (EMBL:AF126376) Streptomyces viridosporus cellulose binding protein CelS2, 358 aa; fasta scores: opt: 2109 z-score: 2160.9 E(): 0; 81.9% identity in 364 aa overlap and to SW:GUNA_MICBI Microbispora bispora endoglucanase A precursor (EC 3.2.1.4) (endo-1,4-beta-glucanase) (CELLULASE) CelA, 456 aa; fasta scores: opt: 350 z-score: 363.9 E(): 6.8e-13; 30.6% identity in 278 aa overlap. Contains match to Pfam entry PF00553 CBD_2, Cellulose binding domain. Contains also possible signal peptide sequence.
 
    
0.656
SCO0643
SCF91.03c, possible secreted cellulose-binding protein, len: 228 aa. Similar to several including: Streptomyces coelicolor TR:CAB50949 (EMBL:AL096849) putative secreted cellulose-binding protein SCI11.23 (356 aa), fasta scores opt: 349 z-score: 417.9 E(): 6.7e-16 32.2% identity in 227 aa overlap. Also weakly similar to chitin-binding proteins e.g. Streptomyces olivaceoviridis TR:Q54501 (EMBL:X78535) chitin binding protein precursor (201 aa), fasta scores opt: 203 z-score: 249.8 E(): 1.5e-06 29.3% identity in 222 aa overlap. Contains a possible N-terminal signal sequence.
 
     0.653
SCO2230
SC10B7.25c, malF, putative maltose permease, len: 334 aa; identical to previously sequenced TR:P72398 (EMBL:Y07706) Streptomyces coelicolor putative maltose permease MalF, 334 aa and similar to SW:MALF_ECOLI (EMBL:J01648) Escherichia coli maltose transport system permease protein MalF, 514 aa; fasta scores: opt: 424 z-score: 504.4 E(): 1e-20; 33.9% identity in 239 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane c [...]
   
  
 0.647
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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