STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO1378Putative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)    
Predicted Functional Partners:
SCO5471
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
SCO5472
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
SCO5470
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.996
SCO4837
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.994
SCO5364
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.994
SCO5281
SCCB12.05c, probable 2-oxoglutarate dehydrogenase, len: 1272 aa; similar to TR:P96746 (EMBL:D84102) Corynebacterium glutamicum 2-oxoglutarate dehydrogenase (EC 1.2.4.2) OdhA, 1257 aa; fasta scores: opt: 4321 z-score: 3452.7 E(): 0; 54.8% identity in 1262 aa overlap and to SW:ODO1_ECOLI (EMBL:J01619) Escherichia coli 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) SucA, 933 aa; fasta scores: opt: 2568 z-score: 2056.0 E(): 0; 46.5% identity in 881 aa overlap. Contains Pfam matches to entries PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and PF0 [...]
  
  
 0.974
SCO4068
SCD25.04, purD, phosphoribosylamine-glycine ligase (EC 6.3.4.13), len: 416 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:PUR2_MYCTU (EMBL; Z80226) phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) MTCY369.17 (422 aa), fasta scores opt: 957 z-score: 1033.0 E(): 0 58.3% identity in 424 aa overlap. Contains a PS00184 Phosphoribosylglycinamide synthetase signature and a Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS).
  
  
 0.972
SCO2026
SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap).
   
 0.969
SCO1087
2SCG4.03c, probable aldolase, len: 356 aa; similar to TR:O50584 (EMBL:AB001577) Pseudomonas sp. low specificity L-threonine aldolase, 346 aa; fasta scores: opt: 832 z-score: 977.3 E(): 0; 41.3% identity in 339 aa overlap and to SW:LTAA_AERJA (EMBL:D87890) Aeromonas jandaei L-allo-threonine aldolase (EC 4.1.2.-) LtaA, 338 aa; fasta scores: opt: 270 z-score: 321.1 E(): 2.1e-10; 26.9% identity in 324 aa overlap.
 
  
 0.961
SCO2180
SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...]
 
 
 0.960
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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