node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1180 | SCO1380 | gene:17758763 | gene:17758963 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.844 |
SCO1180 | SCO1739 | gene:17758763 | gene:17759333 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | SCI11.28c, probable DNA polymerase III, alpha chain, len: 1185 aa; similar to many e.g. SW:DP3A_ECOLI (EMBL:M19334), dnaE, Escherichia coli DNA polymerase III, alpha chain (1160 aa), fasta scores; opt: 1177 z-score: 1220.7 E(): 0, 28.4% identity in 1135 aa overlap; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. | 0.807 |
SCO1180 | SCO3878 | gene:17758763 | gene:17761505 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.413 |
SCO1180 | SCO5769 | gene:17758763 | gene:17763429 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.875 |
SCO1180 | SCO5803 | gene:17758763 | gene:17763463 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.505 |
SCO1180 | dnaN | gene:17758763 | gene:17765624 | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | Putative DNA-polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.436 |
SCO1379 | SCO1380 | gene:17758962 | gene:17758963 | SC10A9.21, hypothetical protein, len: 131 aa; similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c, 131 aa; fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06; 33.3% identity in 96 aa overlap. | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.854 |
SCO1379 | SCO1381 | gene:17758962 | gene:17758964 | SC10A9.21, hypothetical protein, len: 131 aa; similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c, 131 aa; fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06; 33.3% identity in 96 aa overlap. | SC1A8A.01c, partial CDS, hypothetical protein, len: >183aa; similar to SW:Q50603 (Y0DD_MYCTU) hypothetical protein from Mycobacterium tuberculosis (225 aa) fasta scores; opt: 641, z-score: 633.8, E(): 7.1e-28, 64.7% identity in 150 aa overlap. Note possible alternative translational start sites downstream; SC10A9.23c, conserved hypothetical protein (fragment), len: >78 aa; similar to SW:YI30_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical 24.0 kDa protein MTCY1A11.13c, 225 aa; fasta scores: opt: 269 z-score: 377.2 E(): 1.4e-13; 56.0% identity in 75 aa overlap. | 0.782 |
SCO1379 | SCO1382 | gene:17758962 | gene:17758965 | SC10A9.21, hypothetical protein, len: 131 aa; similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c, 131 aa; fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06; 33.3% identity in 96 aa overlap. | SC1A8A.02c, conserved hypothetical protein, len: 157aa; similar to many eg. SW:Q50604 (Y0DE_MYCTU) hypothetical protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 592, z-score: 709.0, E(): 4.6e-32, 60.2% identity in 161 aa overlap. | 0.880 |
SCO1379 | SCO1739 | gene:17758962 | gene:17759333 | SC10A9.21, hypothetical protein, len: 131 aa; similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c, 131 aa; fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06; 33.3% identity in 96 aa overlap. | SCI11.28c, probable DNA polymerase III, alpha chain, len: 1185 aa; similar to many e.g. SW:DP3A_ECOLI (EMBL:M19334), dnaE, Escherichia coli DNA polymerase III, alpha chain (1160 aa), fasta scores; opt: 1177 z-score: 1220.7 E(): 0, 28.4% identity in 1135 aa overlap; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. | 0.696 |
SCO1380 | SCO1180 | gene:17758963 | gene:17758763 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...] | 0.844 |
SCO1380 | SCO1379 | gene:17758963 | gene:17758962 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SC10A9.21, hypothetical protein, len: 131 aa; similar to TR:Q9RJP4 (EMBL:AL132991) Streptomyces coelicolor hypothetical 14.5 kDa protein SCF55.21c, 131 aa; fasta scores: opt: 195 z-score: 246.8 E(): 2.7e-06; 33.3% identity in 96 aa overlap. | 0.854 |
SCO1380 | SCO1381 | gene:17758963 | gene:17758964 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SC1A8A.01c, partial CDS, hypothetical protein, len: >183aa; similar to SW:Q50603 (Y0DD_MYCTU) hypothetical protein from Mycobacterium tuberculosis (225 aa) fasta scores; opt: 641, z-score: 633.8, E(): 7.1e-28, 64.7% identity in 150 aa overlap. Note possible alternative translational start sites downstream; SC10A9.23c, conserved hypothetical protein (fragment), len: >78 aa; similar to SW:YI30_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical 24.0 kDa protein MTCY1A11.13c, 225 aa; fasta scores: opt: 269 z-score: 377.2 E(): 1.4e-13; 56.0% identity in 75 aa overlap. | 0.896 |
SCO1380 | SCO1382 | gene:17758963 | gene:17758965 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SC1A8A.02c, conserved hypothetical protein, len: 157aa; similar to many eg. SW:Q50604 (Y0DE_MYCTU) hypothetical protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 592, z-score: 709.0, E(): 4.6e-32, 60.2% identity in 161 aa overlap. | 0.954 |
SCO1380 | SCO1739 | gene:17758963 | gene:17759333 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SCI11.28c, probable DNA polymerase III, alpha chain, len: 1185 aa; similar to many e.g. SW:DP3A_ECOLI (EMBL:M19334), dnaE, Escherichia coli DNA polymerase III, alpha chain (1160 aa), fasta scores; opt: 1177 z-score: 1220.7 E(): 0, 28.4% identity in 1135 aa overlap; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. | 0.914 |
SCO1380 | SCO1966 | gene:17758963 | gene:17759563 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | ABC excision nuclease subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] | 0.799 |
SCO1380 | SCO3878 | gene:17758963 | gene:17761505 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.840 |
SCO1380 | SCO5769 | gene:17758963 | gene:17763429 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.871 |
SCO1380 | SCO5803 | gene:17758963 | gene:17763463 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.940 |
SCO1380 | dnaN | gene:17758963 | gene:17765624 | Putative DNA damage inducible protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Putative DNA-polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.836 |