STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1464Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)    
Predicted Functional Partners:
SCO6497
SC1E6.06, tktA2, probable transketolase, len: 615 aa; highly similar to eukaryotic transketolases e.g. TKT_HUMAN transketolase (EC 2.2.1.1) (623 aa), fasta scores; opt: 1909 z-score: 2169.3 E(): 0, 50.0% identity in 614 aa overlap; less similar to prokaryotic transketolases e.g. TKT_RHOSH transketolase (657 aa), fasta scores; opt: 477 z-score: 830.4 E(): 0, 31.3% identity in 635 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 397.70, E-value 1.1e-115. Also similar to S. coelicolor tkt (SC5A7.13c) E(): 4.2e-20, 2 [...]
 
 0.991
SCO1935
Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
 0.980
SCO6663
SC5A7.13c, tktB, probable transketolase, len: 698 aa; highly similar to many e.g. TKT2_ECOLI transketolase 2 (EC 2.2.1.1) (667 aa), fasta scores; opt: 1191 z-score: 1912.7 E(): 0, 46.0% identity in 683 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 1163.10, E-value 0; Belongs to the transketolase family.
 0.980
SCO0579
Putative ribose 5-phosphate isomerase; SCF55.03c, possible sugar-phosphate isomerase, len: 170 aa; similar to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) (phosphoriboisomerase B) RpiB, 149 aa; fasta scores: opt: 299 z-score: 364.4 E(): 6.3e-13; 38.5% identity in 148 aa overlap.
 
 
 0.965
SCO0975
6-phosphogluconate 1-dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
   
 0.952
SCO2627
SC8E4.02c, probable sugar-phosphate isomerase, len: 159 aa; similar to TR:O53192 (EMBL:AL021246) Mycobacterium tuberculosis putative isomerase MTV008.21c, 162 aa; fasta scores: opt: 665 z-score: 811.6 E(): 0; 62.1% identity in 153 aa overlap and to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) (phosphoriboisomerase B) RpiB, 149 aa; fasta scores: opt: 294 z-score: 366.6 E(): 5.2e-13; 37.5% identity in 144 aa overlap.
 
 
 0.938
SCO1224
2SCG58.24c, possible sugar-phosphate isomerase, len: 152 aa; similar to SW:RPIB_ECOLI (EMBL:X82203) Escherichia coli ribose 5-phosphate isomerase B (EC 5.3.1.6) RpiB, 149 aa; fasta scores: opt: 248 z-score: 314.7 E(): 4.6e-10; 36.6% identity in 134 aa overlap.
 
 
 0.936
SCO1170
Xylulose kinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate; Belongs to the FGGY kinase family.
   
 0.923
SCO2462
SC7A8.01, probable sugar kinase (fragment), len: >434 aa; similar to TR:CAB61582 (EMBL:AL133210) Streptomyces coelicolor xylulose kinase (fragment) XylB, 432 aa; fasta scores: opt: 822 z-score: 871.9 E(): 0; 38.8% identity in 418 aa overlap and to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB, 481 aa; fasta scores: opt: 814 z-score: 862.8 E(): 0; 39.5% identity in 423 aa overlap. Contains Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases and PS00445 FGGY family of carbohydrate kinases signature 2; SCC24.33, probable sugar ki [...]
   
 0.923
SCO3877
SCH18.14c, probable 6-phosphogluconate dehydrogenase, len: 291 aa; identical to previously sequenced TR:Q53917 (EMBL:L27063) Streptomyces coelicolor 6-phosphogluconate dehydrogenase, 291 aa and highly similar to TR:O88014 (EMBL:AL031107) S. coelicolor SC5A7.08c probable 6-phosphogluconate dehydrogenase, 293 aa; fasta scores: opt: 1654 z-score: 1688.1 E(): 0; 83.4% identity in 289 aa overlap. Contains Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenasesand match to Prosite entry.
    
 0.910
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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