STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1508SC9C5.32c, hisS, histidyl tRNA synthetase, len: 425 aa; similar to SW:SYH_ECOLI (EMBL:M11843) Escherichia coli histidyl tRNA synthetase (EC 6.1.1.21) HisS, 423 aa; fasta scores: opt: 1054 z-score: 1173.7 E(): 0; 42.3% identity in 421 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). (425 aa)    
Predicted Functional Partners:
SCO3795
aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
  
 0.977
SCO1438
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 
 0.922
SCO2615
Valyl tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
 
 0.884
SCO1509
SC9C5.33c, possible hydrolase, len: 235 aa; similar to SW:YCBL_ECOLI (EMBL:AE000195) Escherichia coli hypothetical 23.8 kD protein in MukB-AspC intergenic region YcbL, 215 aa; fasta scores: opt: 284 z-score: 328.0 E(): 8.4e-11; 32.6% identity in 215 aa overlap and to TR:CAB83688 (EMBL:AL162753) Neisseria meningitidis putative hydrolase NMA0387, 210 aa; fasta scores: opt: 239 z-score: 277.9 E(): 5.2e-08; 32.5% identity in 206 aa overlap. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.
  
    0.877
SCO1531
threonine-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
  
 
 0.815
SCO3778
SCH63.25, possible threonyl tRNA synthetase, len: 430 aa; highly similar to C-terminal region of many threonyl tRNA synthetases, e.g. SW:SYT1_BACSU (EMBL:M36594) Bacillus subtilis threonyl tRNA synthetase 1 (EC 6.1.1.3) ThrS, 643 aa; fasta scores: opt: 1274 z-score: 1489.5 E(): 0; 50.9% identity in 379 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T).
 
 
 0.785
SCO4785
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.784
SCO1510
SC9C5.34, possible peptidyl-prolyl cis-trans isomerase, len: 277 aa; similar to SW:CYPB_MYCLE (EMBL:U00011) Mycobacterium leprae probable peptidyl-prolyl cis-trans isomerase PpiB or MLCB1259.10c, 295 aa; fasta scores: opt: 514 z-score: 573.6 E(): 1.8e-24; 40.0% identity in 295 aa overlap and to SW:CYPB_BACSU (EMBL:L09228) Bacillus subtilis peptidyl-prolyl cis-trans isomerase PpiB, 143 aa; fasta scores: opt: 240 z-score: 276.9 E(): 5.9e-08; 37.0% identity in 127 aa overlap. Contains Pfam match to entry PF00160 pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase. Contains [...]
       0.771
SCO1507
SC9C5.31c, possible integral membrane protein, len: 240 aa; similar to TR:O69464 (EMBL:AL023635) Mycobacterium leprae putative integral membrane protein MLCB1243.07, 214 aa; fasta scores: opt: 511 z-score: 600.4 E(): 5.7e-26; 36.1% identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.766
SCO1505
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
  
 0.761
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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