node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0978 | SCO1522 | gene:17758561 | gene:17759108 | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.830 |
SCO0978 | SCO1523 | gene:17758561 | gene:17759109 | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.834 |
SCO0978 | SCO3383 | gene:17758561 | gene:17761005 | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.999 |
SCO0978 | SCO4387 | gene:17758561 | gene:17762032 | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | Putative pyridoxamine oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.713 |
SCO1521 | SCO1522 | gene:17759107 | gene:17759108 | SCL2.11c, hypothetical protein, len: 250 aa; similar to various hypothetical proteins, e.g. TR:YQ03_MYCTU (EMBL:Z98045) Mycobacterium tuberculosis hypothetical 26.8 kD protein RV2603c, 251 aa; fasta scores: opt: 1268 z-score: 1388.1 E(): 0; 76.7% identity in 249 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.975 |
SCO1521 | SCO1523 | gene:17759107 | gene:17759109 | SCL2.11c, hypothetical protein, len: 250 aa; similar to various hypothetical proteins, e.g. TR:YQ03_MYCTU (EMBL:Z98045) Mycobacterium tuberculosis hypothetical 26.8 kD protein RV2603c, 251 aa; fasta scores: opt: 1268 z-score: 1388.1 E(): 0; 76.7% identity in 249 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.974 |
SCO1522 | SCO0978 | gene:17759108 | gene:17758561 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.830 |
SCO1522 | SCO1521 | gene:17759108 | gene:17759107 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | SCL2.11c, hypothetical protein, len: 250 aa; similar to various hypothetical proteins, e.g. TR:YQ03_MYCTU (EMBL:Z98045) Mycobacterium tuberculosis hypothetical 26.8 kD protein RV2603c, 251 aa; fasta scores: opt: 1268 z-score: 1388.1 E(): 0; 76.7% identity in 249 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.975 |
SCO1522 | SCO1523 | gene:17759108 | gene:17759109 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.999 |
SCO1522 | SCO1935 | gene:17759108 | gene:17759532 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.800 |
SCO1522 | SCO1936 | gene:17759108 | gene:17759533 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.817 |
SCO1522 | SCO3383 | gene:17759108 | gene:17761005 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.825 |
SCO1522 | SCO4387 | gene:17759108 | gene:17762032 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Putative pyridoxamine oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.990 |
SCO1522 | SCO4418 | gene:17759108 | gene:17762063 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | SC6F11.16c, probable oxidase, len: 222 aa; similar to TR:O88794 (EMBL:U91561) Rattus norvegicus pyridoxine 5'-phosphate oxidase PnpO, 261 aa; fasta scores: opt: 413 z-score: 479.7 E(): 3.2e-19; 38.0% identity in 184 aa overlap. Contains Pfam match to entry PF01243 Pyridox_oxidase, Pyridoxamine 5'-phosphate oxidase. | 0.917 |
SCO1522 | SCO6497 | gene:17759108 | gene:17764154 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | SC1E6.06, tktA2, probable transketolase, len: 615 aa; highly similar to eukaryotic transketolases e.g. TKT_HUMAN transketolase (EC 2.2.1.1) (623 aa), fasta scores; opt: 1909 z-score: 2169.3 E(): 0, 50.0% identity in 614 aa overlap; less similar to prokaryotic transketolases e.g. TKT_RHOSH transketolase (657 aa), fasta scores; opt: 477 z-score: 830.4 E(): 0, 31.3% identity in 635 aa overlap. Contains PS00802 Transketolase signature 2 and Pfam match to entry PF00456 transketolase, Transketolase, score 397.70, E-value 1.1e-115. Also similar to S. coelicolor tkt (SC5A7.13c) E(): 4.2e-20, 2 [...] | 0.800 |
SCO1522 | SCO6662 | gene:17759108 | gene:17764320 | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.817 |
SCO1523 | SCO0978 | gene:17759109 | gene:17758561 | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.834 |
SCO1523 | SCO1521 | gene:17759109 | gene:17759107 | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | SCL2.11c, hypothetical protein, len: 250 aa; similar to various hypothetical proteins, e.g. TR:YQ03_MYCTU (EMBL:Z98045) Mycobacterium tuberculosis hypothetical 26.8 kD protein RV2603c, 251 aa; fasta scores: opt: 1268 z-score: 1388.1 E(): 0; 76.7% identity in 249 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.974 |
SCO1523 | SCO1522 | gene:17759109 | gene:17759108 | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.999 |
SCO1523 | SCO1935 | gene:17759109 | gene:17759532 | Conserved hypothetical protein SCL2.13c; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.815 |