STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1554Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1212 aa)    
Predicted Functional Partners:
SCO1553
SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...]
 
  
 0.982
SCO1857
SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...]
 
  
 0.979
SCO1847
Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.957
SCO2173
SC5F7.28, putative adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase, len: 397 aa; regions similar to different proteins. 1-220aa similar to TR:O05479 (EMBL:M86351) triacylglycerol acylhydrolase from Streptomyces sp. (481 aa) fasta scores; opt: 146, z-score: 158.6, E(): 0.17, (30.4% identity in 207 aa overlap). 220-397aa similar to many bifunctional adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase proteins in the biosynthesis of cobalamin (vitamin B12) eg. SW:COBU_SALTY adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltra [...]
  
 0.955
SCO2299
SCC30.07c, possible bifunctional protein (ribonuclease H/phosphoglycerate mutase), len: 497 aa; N-terminal region similar to TR:Q9X7R6 (EMBL:AL049863) Streptomyces coelicolor putative ribonuclease H SC5H1.08c, 235 aa; blastp scores: Score = 185 (65.1 bits), Expect = 9.5e-14, P = 9.5e-14 Identities = 82/230 (35%), Positives = 105/230 (45%) and C-terminal region similar to TR:O67797 (EMBL:AE000766) Aquifex aeolicus phosphoglycerate mutase PgmA, 212 aa; fasta scores: opt: 355 z-score: 327.3 E(): 8.7e-11; 32.8% identity in 201 aa overlap. Contains Pfam match to entry PF00075 rnaseH, RNase [...]
 
 
 0.947
SCO1555
SCL11.11c, probable methyltransferase, len: 408 aa; similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE, 425 aa; fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15; 29.9% identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE, 201 aa; fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08; 33.3% identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases.
 
  
 0.942
SCO1852
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.941
SCO1848
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.933
SCO2175
Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
 
 
0.929
SCO2177
Putative cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.918
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.