STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO1559Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (368 aa)    
Predicted Functional Partners:
SCO1557
SCL11.13c, possible lipoprotein, len: 275 aa; similar to TR:AAD51879 (EMBL:AF102556) Salmonella enteritidis liporpotein SfbA, 276 aa; fasta scores: opt: 519 z-score: 578.9 E(): 8e-25; 38.0% identity in 258 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence; Belongs to the nlpA lipoprotein family.
 
 0.999
SCO1558
SCL11.14c, probable ABC transporter permease protein, len: 240 aa; similar to TR:AAF10929 (EMBL:AE001982) Deinococcus radiodurans ABC transporter, permease protein DR1357, 218 aa; fasta scores: opt: 721 z-score: 842.8 E(): 0; 57.7% identity in 213 aa overlap and to SW:PROW_BACSU (EMBL:U38418) Bacillus subtilis glycine betaine/L-proline transport system permease protein ProW, 217 aa; fasta scores: opt: 212 z-score: 255.8 E(): 7.9e-07; 28.4% identity in 194 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component.
 
 0.999
SCO4017
2SC10A7.21c, desR2, iron dependent repressor, len: 238 aa; highly similar to TR:CAB95905 (EMBL:AL359988) Streptomyces coelicolor iron repressor DesR, 230 aa; fasta scores: opt: 1140 z-score: 1122.3 E(): 0; 76.3% identity in 236 aa overlap and to SW:IDER_MYCTU (EMBL:U14191) Mycobacterium tuberculosis iron-dependent repressor IdeR, 230 aa; fasta scores: opt: 761 z-score: 754.0 E(): 0; 61.6% identity in 237 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor.
   
   0.769
SCO4394
Iron repressor; SCD10.26, desR, probable iron repressor, len: 230 aa; identical to TR:Q54343 (EMBL:Z50049) Streptomyces lividans putative iron repressor DesR, 230 aa. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor. Contains also a possible helix-turn-helix motif at residues 25..46 (+2.65 SD).
   
   0.769
SCO2103
SC4A10.36c, metF, 5,10-methylenetetrahydrofolate reductase, len: 307 aa; identical to SW:METF_STRLI (EMBL:AJ001630), MetF, Streptomyces lividans 5,10-methylenetetrahydrofolate reductase (307 aa), apart from substitution of Arg41 for Lys41 in S.coelicolor, fasta scores; opt: 2015 z-score: 2364.3 E(): 0, 99.7% identity in 307 aa overlap.
   
  
 0.765
SCO1554
Putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
     
 0.742
SCO1553
SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...]
     
 0.729
SCO1560
SCL11.16c, possible phosphatase, len: 216 aa; similar to TR:P96428 (EMBL:Z79692) Sinorhizobium meliloti ORF24, 233 aa; fasta scores: opt: 488 z-score: 573.6 E(): 1.6e-24; 42.2% identity in 206 aa overlap and to TR:BAA16133 (EMBL:D90861)Escherichia coli 2-deoxyglucose-6-phosphate phosphatase 1 (EC 3.1.3.-) Dog1, 222aa; fasta scores: opt: 430 z-score: 507.0 E(): 8.1e-21; 36.2% identity in 213 aa overlap.
     
 0.727
SCO1556
SCL11.12c, possible acetyltransferase, len: 232 aa; similar to TR:CAB59477 (EMBL:AL132648) Streptomyces coelicolor putative acetyltransferase SCI41.07c, 196 aa; fasta scores: opt: 245 z-score: 310.5 E(): 7.1e-10; 33.7% identity in 175 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
       0.722
SCO1476
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.698
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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