STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO1579Putative glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa)    
Predicted Functional Partners:
SCO1577
SCL24.13c, argD, acetonitrile aminotransferase, len: 402 aa; highly similar to SW:ARGD_CORGL (EMBL:X86157) Corynebacterium glutamicum acetylornithine aminotransferase (EC 2.6.1.11) ArgD, 389 aa; fasta scores: opt: 1247 z-score: 1362.1 E(): 0; 52.0% identity in 379 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
 
 0.999
SCO1578
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 0.999
SCO1580
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.999
SCO1576
Arginine repressor; Regulates arginine biosynthesis genes.
  
  
 0.998
SCO5976
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
 
 0.997
SCO7036
SC4G1.02, argG, argininosuccinate synthase, len: 481 aa; identical to previously sequenced SW:ASSY_STRCO (EMBL:D00799) Streptomyces coelicolor argininosuccinate synthase (EC 6.3.4.5) ArgG, 480 aa. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase and matches to Prosite entries PS00564 Argininosuccinate synthase signature 1 and PS00565 Argininosuccinate synthase signature 2; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
  
  
 0.986
SCO1570
SCL24.06c, argH, argininosuccinate lyase, len: 475 aa; highly similar to SW:ARLY_CORGL (EMBL:AF049897) Corynebacterium glutamicum argininosuccinate lyase (EC 4.3.2.1) ArgH, 478 aa; fasta scores: opt: 1473 z-score: 1658.6 E(): 0; 59.1% identity in 391 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and two matches to Prosite entries PS00163 Fumarate lyases signature and PS00017 ATP/GTP-binding site motif A (P-loop).
 
  
 0.984
SCO3376
SCE94.27c, possible acetyltransferase, len: 169aa; similar to hypothetical proteins eg. TR:O33289 (EMBL:AL008967) from Mycobacterium tuberculosis (174 aa) fasta scores; opt: 656, z-score: 842.4, E(): 0, (60.4% identity in 164 aa overlap). Also some similarity to SW:ARGA_ECOLI ArgA, amino-acid acetyltransferase from Escherichia coli (443 aa) fasta scores; opt: 192, z-score: 248.7, E(): 1.5e-06, (29.0% identity in 138 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
 
 
 0.965
SCO4683
SCD31.08, gdhA, NADP-specific glutamate dehydrogenase, len: 461 aa; similar to TR:O87403 (EMBL:AF056335) Bacillus licheniformis NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 460 aa; fasta scores: opt: 1759 z-score: 1940.3 E(): 0; 59.1% identity in 435 aa overlap and to SW:DHE4_ECOLI (EMBL:J01615) Escherichia coli NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 447 aa; fasta scores: opt: 1683 z-score: 1856.8 E(): 0; 58.7% identity in 446 aa overlap. Contains Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase and match to P [...]
     
 0.919
SCO4645
SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
  
 
 0.911
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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