STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1622Putative 5'-3' exonuclease; 5'-3' exonuclease acting preferentially on double-stranded DNA. (301 aa)    
Predicted Functional Partners:
SCO5188
2SC3B6.12, probable ATP-dependent DNA helicase, len: 785 aa; similar to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD, 720 aa; fasta scores: opt: 649 z-score: 632.5 E(): 9.2e-28; 31.6% identity in 643 aa overlap. Contains 2x Pfam matches to entry PF00580 UvrD-helicase, UvrD/REP helicase, Pfam match to entry PF00570 HRDC, HRDC domain and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
 
 0.976
SCO1180
SCG11A.11, probable DNA polymerase III beta chain, len: 386 aa; N-terminal region similar to TR:O54191 (EMBL:AL021411) Streptomyces coelicolor putative transcriptional regulator SC7H1.32c, 196 aa; fasta scores: opt: 211 z-score: 244.3 E(): 3.1e-06; 37.2% identity in 196 aa overlap and C-terminal region similar to SW:DP3B_MYCLE (EMBL:L39923) Mycobacterium leprae DNA polymerase III, beta chain (EC 2.7.7.7) DnaN, 399 aa; fasta scores: opt: 285 z-score: 322.3 E(): 1.4e-10; 30.7% identity in 358 aa overlap. Contains match in N-terminal region to Pfam entry PF00376 merR, Bacterial regulatory [...]
  
 0.964
SCO3878
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 0.963
dnaN
Putative DNA-polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]
  
 0.963
SCO5802
SC4H2.23, probable ATP-dependent helicase, len: 664 aa; similar to e.g. DING_ECOLI P27296 probable ATP-dependent helicase dinG (716 aa), fasta scores opt: 272 z-score: 409.8 E(): 1.3e-15, 26.5% identity in 686 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
   
 0.941
SCO5769
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.930
SCO1301
Putative exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.902
SCO3941
Putative serine/threonineprotein kinase; SCD78.08c, probable serine/threonine protein kinase, len: 498 aa, identical to TR:G3694948 (EMBL:AF090690) previously sequenced putative serine/threonine S. coelicolor. Also similar to TR:O69213 (EMBL:AJ224354) serine-threonine phosphatase PrpA from Anabaena sp. strain PCC 7120 (858 aa) fasta scores; opt:102, z-score: 234.4, E(): 9e-06, (26.8% identity in 231 aa overlap) contains PS00070 aldehyde dehydrogenases cysteine active site.
   
 0.902
SCO7358
Hypothetical protein SC9H11.12c; SC9H11.12c, unknown, len: 500 aa.
   
 0.902
SCO4577
SCD16A.06c, probable helicase, len: 676aa; similar to many (both prokaryote and eukaryote) egs. TR:AAD05424 (EMBL:AF047374) RecQ helicase from Neisseria gonorrhoeae (767 aa) fasta scores; opt: 1809, z-score: 1769.1, E(): 0, (50.4% identity in 601 aa overlap) and SW:HUS2_SCHPO ATP-dependent helicase from Schizosaccharomyces pombe (1328 aa) fasta scores; opt: 1013, z-score: 988.7, E(): 0, (40.2% identity in 493 aa overlap). Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain, score 78.40, E-value 1.4e-19.
  
 0.897
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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