Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SCO1640 | SCO1643 | gene:17759233 | gene:17759236 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | 0.988 |
| SCO1640 | SCO1644 | gene:17759233 | gene:17759237 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | 0.977 |
| SCO1640 | SCO1646 | gene:17759233 | gene:17759239 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | Hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.854 |
| SCO1640 | SCO1648 | gene:17759233 | gene:17759241 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.988 |
| SCO1640 | SCO3822 | gene:17759233 | gene:17761446 | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | SCGD3.23c, conserved hypothetical protein, len: 179 aa; unknown function, highly similar to SW:Y0GE_MYCTU (EMBL:Z80343) Mycobacterium tuberculosis hypothetical protein (178 aa), fasta scores; opt: 692 z-score: 731.2 E(): 0, 65.9% identity in 170 aa overlap. | 0.741 |
| SCO1643 | SCO1640 | gene:17759236 | gene:17759233 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.988 |
| SCO1643 | SCO1644 | gene:17759236 | gene:17759237 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | 0.999 |
| SCO1643 | SCO1645 | gene:17759236 | gene:17759238 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | SCI41.28c, hypothetical protein, len: 197 aa. Identical to TR:O87597 (EMBL:AF086832) Streptomyces coelicolor hypothetical 18.6 kD protein and similar to SW:VG59_BPMD2 (EMBL:AF022214) Mycobacteriophage D29 gene 59 protein, 153 aa; fasta scores: opt: 175 z-score: 225.0 E(): 3.7e-05; 35.2% identity in 122 aa overlap. | 0.805 |
| SCO1643 | SCO1646 | gene:17759236 | gene:17759239 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | Hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.996 |
| SCO1643 | SCO1647 | gene:17759236 | gene:17759240 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | SCI41.30c, hypothetical protein, len: 497 aa. Identical to TR:O87595 (EMBL:AF086832) Streptomyces coelicolor hypothetical 65.1 Kd protein, len: 497 aa and similar to TR:Q53081 (EMBL:U26422) Rhodococcus sp. similar to ORF6(1) of Rhodococcus sp. NI86/21, 499 aa; fasta scores: opt: 2019 z-score: 2370.6 E():0; 62.5% identity in 493 aa overlap. Contains also similarities with Streptomyces coelicolor StI41.23c, 453 aa; fasta scores: opt: 962 z-score: 1019.2 E():0; 41.9% identity in 413 aa overlap. | 0.959 |
| SCO1643 | SCO1648 | gene:17759236 | gene:17759241 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.999 |
| SCO1643 | SCO1649 | gene:17759236 | gene:17759242 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | SCI41.32, putative ferredoxin, len: 101 aa. Identical to TR:087593 (EMBL:AF086832) Streptomyces coelicolor putative ferredoxin, len: 101 aa and similar to SW:FER_BACST (SW:P00212) Bacillus stearothermophilus ferredoxin, fasta scores: opt: 153 z-score: 211.3 E(): 0.00021; 33.3% identity in 69 aa overlap. | 0.689 |
| SCO1643 | SCO3822 | gene:17759236 | gene:17761446 | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | SCGD3.23c, conserved hypothetical protein, len: 179 aa; unknown function, highly similar to SW:Y0GE_MYCTU (EMBL:Z80343) Mycobacterium tuberculosis hypothetical protein (178 aa), fasta scores; opt: 692 z-score: 731.2 E(): 0, 65.9% identity in 170 aa overlap. | 0.982 |
| SCO1644 | SCO1640 | gene:17759237 | gene:17759233 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | Conserved hypothetical protein SCI41.23c; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.977 |
| SCO1644 | SCO1643 | gene:17759237 | gene:17759236 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. | 0.999 |
| SCO1644 | SCO1645 | gene:17759237 | gene:17759238 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | SCI41.28c, hypothetical protein, len: 197 aa. Identical to TR:O87597 (EMBL:AF086832) Streptomyces coelicolor hypothetical 18.6 kD protein and similar to SW:VG59_BPMD2 (EMBL:AF022214) Mycobacteriophage D29 gene 59 protein, 153 aa; fasta scores: opt: 175 z-score: 225.0 E(): 3.7e-05; 35.2% identity in 122 aa overlap. | 0.875 |
| SCO1644 | SCO1646 | gene:17759237 | gene:17759239 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | Hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.997 |
| SCO1644 | SCO1647 | gene:17759237 | gene:17759240 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | SCI41.30c, hypothetical protein, len: 497 aa. Identical to TR:O87595 (EMBL:AF086832) Streptomyces coelicolor hypothetical 65.1 Kd protein, len: 497 aa and similar to TR:Q53081 (EMBL:U26422) Rhodococcus sp. similar to ORF6(1) of Rhodococcus sp. NI86/21, 499 aa; fasta scores: opt: 2019 z-score: 2370.6 E():0; 62.5% identity in 493 aa overlap. Contains also similarities with Streptomyces coelicolor StI41.23c, 453 aa; fasta scores: opt: 962 z-score: 1019.2 E():0; 41.9% identity in 413 aa overlap. | 0.960 |
| SCO1644 | SCO1648 | gene:17759237 | gene:17759241 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.999 |
| SCO1644 | SCO1649 | gene:17759237 | gene:17759242 | 20S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. | SCI41.32, putative ferredoxin, len: 101 aa. Identical to TR:087593 (EMBL:AF086832) Streptomyces coelicolor putative ferredoxin, len: 101 aa and similar to SW:FER_BACST (SW:P00212) Bacillus stearothermophilus ferredoxin, fasta scores: opt: 153 z-score: 211.3 E(): 0.00021; 33.3% identity in 69 aa overlap. | 0.694 |
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