STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1659Putative glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)    
Predicted Functional Partners:
SCO1660
Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
 0.992
SCO0509
Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
 
 0.967
SCO1661
SCI52.03, probable glycerol-3-phosphate dehydrogenase, len: 538 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39; 30.830% identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase.
 
  
 0.965
SCO0670
SCF91.30, glpD, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), len: 527 aa. Highly similar to many prokaryotic and eukaryotic glycerol-3-phosphate dehydrogenases including: Mycobacterium tuberculosis SW:GLPD_MYCTU (EMBL:Z70692) (516 aa), fasta scores opt: 1648 z-score: 1727.9 E():0 52.6% identity in 513 aa overlap and Caenorhabditis elegans SW:GPDM_CAEEL(EMBL:Z73906) (722aa), fasta score opt: 668 z-score: 700.9 E(): 1.2e-31 33.9% identity in 537 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and a Prosite hit to PS00 [...]
 
  
 0.917
SCO7004
SC8F11.30, probable carbohydrate kinase,len: 479 aa. Highly similar to many e.g. Bacillus subtilis SW:GLPK_BACSU(EMBL:M34393) glycerol kinase (EC 2.7.1.30), GlpK (496 aa), fasta scores opt: 688 z-score: 766.4 E():0 35.1% identity in 496 aa overlap. Contains a Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases.
 
 
 0.894
SCO4774
SCD63.06, probable glycerol phosphate dehydrogenase, len: 568 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 815 z-score: 910.2 E(): 0; 32.1% identity in 546 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and match to Prosite entry PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2.
 
  
 0.842
SCO1658
Glycerol operon regulatory protein; May be an activator protein for the gylABX operon.
     
 0.830
SCO3196
SCE22.13c, probable fructose-specific permease, len: 699 aa; similar to SW:PTFB_ECOLI (EMBL:M23196) Escherichia coli PTS system, fructose-specific IIBC component (EIIBC-fru) FruA 563 aa; fasta scores: opt: 1006 z-score: 1038.9 E(): 0; 43.7% identity in 583 aa overlap. Contains match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and possible hydrophobic membrane spanning regions in C-terminal domain.
  
  
 0.726
SCO0141
SCJ33.05c, possible calcium-binding protein, len: 183 aa. Weakly similar to many Eukaryotic calcium-binding proteins e.g. Drosophila melanogaster (Fruit fly) TR:O16158 (EMBL:AF014952) calcium-binding protein (184 aa), fasta scores opt: 265 z-score: 323.1 E(): 1.2e-10 28.1% identity in 178 aa overlap. Contains a 4xPfam match to entry PF00036 efhand, EF hand.
   
 
 0.704
SCO4411
SC6F11.09, probable calcium binding protein, len: 170 aa; similar to SW:CBP_SACER (EMBL:M29700) Saccharopolyspora erythraea calerythrin (calcium-binding protein), 177 aa; fasta scores: opt: 229 z-score: 267.7 E(): 2.1e-07; 28.6% identity in 154 aa overlap. Contains 4x Pfam matches to entry PF00036 efhand, EF hand and 3x matches to Prosite entry PS00018 EF-hand calcium-binding domain.
   
 
 0.704
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.