STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1867Putative hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. (280 aa)    
Predicted Functional Partners:
SCO1866
Putative condensing enzyme; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant.
 
  
 0.998
SCO1865
Putative aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.989
SCO1864
Putative acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.
 
   
 0.961
SCO5799
SC4H2.20, probable aminotransferase, len: 532; similar to many e.g. GABT_ECOLI P22256 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 355 z-score: 385.5 E(): 3e-14, 28.8% identity in 427 aa overlap. Contains two repetitive regions: GSGSGTGPGSGTGPGTGTGPGTGPGTGPG between aa 82-104, and VTVTDAVTVTDAVTDADADAD between aa 241-261, that are not present in other aminotransferases. Also contains 2x match to Pfam match to entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, scores 72.94 and 175.90, and TTA leucine codon; a potential target for actionof bldA.
 
  
 0.727
SCO7034
SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...]
 
  
 0.619
SCO1861
SCI39.08c, conserved hypothetical protein, len: 363 aa; similar to SW:YT15_MYCTU (EMBL:Z74697) Mycobacterium tuberculosis hypothetical 39.8 kDa protein RV2915c, 370 aa; fasta scores: opt: 1341 Z-score: 1487.0 bits: 283.8 E(): 3.1e-75; 56.630% identity in 362 aa overlap.
       0.615
SCO2828
SCE20.02, probable amino acid ABC transporter protein, solute-binding component, len: 309 aa. Similar to several including: Salmonella typhimurium SW:ARGT_SALTY(EMBL:V01368) lysine-arginine-ornithine-binding periplasmic protein precursor (260 aa), fasta scores opt: 251 z-score: 294.5 E(): 5.1e-09 25.8% identity in 279 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TE_RHISN(EMBL:AE000098) probable amino-acid ABC transporter periplasmic binding protein Y4TE (300 aa), fasta scores opt: 599 z-score: 691.7 E(): 3.8e-31 35.4% identity in 297 aa overlap. Contains a Pfam match to entry PF00 [...]
 
   
 0.593
SCO6564
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
      
 0.564
SCO6412
SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...]
  
  
 0.542
SCO2822
SCBAC17F8.13c, possible decarboxylase, len: 243 aa: similar to many e.g. SW:Q05115 (AMDA_BORBR) arylmalonate decarboxylase from Alcaligenes bronchisepticus (240 aa) fasta scores; opt: 258, Z-score: 293.3, 33.333% identity (34.302% ungapped) in 177 aa overlap. Almost identical to TR:Q54412 (EMBL:X52071) hypothetical protein which close alongside transfer RNA-gly in Streptomyces lividans (195 aa) fasta scores; opt: 1233, Z-score: 1358.6, 98.980% identity (99.487% ungapped) in 196 aa overlap. Also similar to neighbouring CDS SCBAC17F8.14c.
  
     0.506
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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