STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO2048Putative hisF, cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (251 aa)    
Predicted Functional Partners:
SCO2050
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan; Belongs to the HisA/HisF family.
 
0.999
SCO2051
hisH, amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 0.999
SCO2052
SC4G6.21c, hisB, imidazoleglycerol-phosphate dehydratase, len: 197aa; previously sequenced therefore identical to SW:HIS7_STRCO. Contains Pfam match to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase and Prosite matches to PS00955 Imidazoleglycerol-phosphate dehydratase signature 2 and PS00954 Imidazoleglycerol-phosphate dehydratase signature 1.
 
 
 0.999
SCO2054
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
SCO1438
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.992
SCO2044
Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.991
SCO2053
SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
 
  
 0.988
SCO1439
SC6D7A.02c, hisE, phosphoribosyl-ATP pyrophosphatase, len: 90 aa; similar to SW:HIS2_SULSO (EMBL:U82227) Sulfolobus solfataricus phosphoribosyl-ATP pyrophosphatase HisE (EC 3.6.1.31), 94 aa; fasta scores: opt: 175 z-score: 245.2 E(): 4e-06; 33.3% identity in 90 aa overlap and to SW:HIS2_MYCTU (EMBL:Z97559) Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphatase HisE (EC 3.6.1.31), 93 aa; fasta scores: opt: 336 z-score: 452.1 E(): 1.2e-17; 60.0% identity in 90 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase.
 
  
 0.982
SCO0479
SCF76.19c, putative phosphatase, len: 274 aa. Almost identical to Streptomyces lividans TR:O70034 (EMBL; AJ223365) Sbl1 gene (274 aa), fasta scores opt: 1764 z-score: 2005.4 E():0 97.1% identity in 274 aa overlap. Also weakly similar to many inositol monophosphatases e.g. Mycobacterium smegmatis TR:O51845 (EMBL; AF005905) inositol monophosphate phosphatase (276 aa), fasta scores opt: 299 z-score: 346.7 E(): 6e-12 33.1% identity in 269 aa overlap and Escherichia coli SW: SUHB_ECOLI (EMBL; M34828) extragenic suppressor protein SuhB (267 aa), fasta scores opt: 269 z-score: 313.0 E(): 4.6e [...]
  
  
 0.941
SCO3944
Putative histidinol-phophate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.887
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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