STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO2074Putative signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (204 aa)    
Predicted Functional Partners:
SCO2034
Putative prolipoprotein diacyleglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
 
   
 0.954
SCO7822
Probable prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.; Belongs to the Lgt family.
 
   
 0.951
SCO1014
Putative transferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
   
 0.912
SCO1336
Putative lipoprotein N-acyltransferase (integral membrane); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
   
 0.912
SCO2075
SC4A10.08c, probable DNA-binding protein, len: 239 aa; the N-terminus is Lys- and Ala-rich, containing 13 degenerate AAKK(S)(P/T) repeats and is similar to histone-like proteins e.g. SW:KARP_CHLTR (EMBL:M86605), KarP, Chlamydia trachomatis developmentally regulated gene (207 aa), fasta scores; opt: 245 z-score: 253.5 E(): 8.5e-07, 44.7% identity in 114 aa overlap. This region is also similar to a repeat in TR:O86537 (EMBL:AL031124) S.coelicolor histone-like DNA binding protein (218 aa) (51.4% identity in 72 aa overlap). The C-terminus is similar to SW:DKSA_ECOLI (EMBL:M34945), DskA, Es [...]
  
    0.813
SCO2073
Putative ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
  
    0.798
SCO2072
SC4A10.05c, hypothetical protein, len: 160 aa; unknown function, shows weak similarity to hypothetical proteins from other eubacteria e.g. SW:YYBD_BACSU (EMBL:D26185) Bacillus subtilis hypothetical protein (147 aa), fasta scores; opt: 199 z-score: 236.4 E(): 7.6e-06, 36.8% identity in 144 aa overlap. Shows weak similarity to SC5F7.12c (EMBL:AL096872) S.coelicolor possible acetyltransferase (169 aa) (37.7% identity in 114 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
       0.769
SCO2069
SC4A10.02c, hypothetical protein, len: 196 aa; similar to the plasmid borne TR:CAC48425 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMB20022, 188 aa; fasta scores: opt: 485 Z-score: 576.0 E(): 1.9e-24; 45.198% identity in 177 aa overlap. Probable CDS suggested by GC frameplot, positional base preference and amino acid composition. Annotated in cosmid 4G6 as SC4G6.38c.
     
 0.747
SCO3410
SCE9.17, possible membrane protein, len: 578 aa; similar to TR:O69704 (EMBL:AL022121) Mycobacterium tuberculosis putative membrane protein (529 aa), fasta scores; opt: 642 z-score: 677.3 E(): 2.1e-30, 31.6% identity in 481 aa overlap. The start codon is uncertain as there are 2 potential. The general position of the CDS start was estimated by GC frame plot. Contains hydrophobic, possible membrane-spanning regions in the C-terminal half, while the N-terminal half is more hydrophilic.
     
 0.737
SCO2088
Putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
 
  
 0.734
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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