node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO2104 | SCO2107 | gene:17759702 | gene:17759705 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | 0.886 |
SCO2104 | SCO2108 | gene:17759702 | gene:17759706 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | 0.973 |
SCO2104 | SCO2109 | gene:17759702 | gene:17759707 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.992 |
SCO2104 | SCO3928 | gene:17759702 | gene:17761555 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.919 |
SCO2104 | SCO3938 | gene:17759702 | gene:17761565 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | SCD78.05, thiC', probable thiamin biosynthesis protein ThiC, partial CDS, len: 43 aa; simlar to the extreme C-terminus of e.g. THIC_ECOLI thiamin biosynthesis protein ThiC (631 aa), fasta scores; opt: 97 z-score: 137.7 E(): 2, 46.2% identity in 39 aa overlap and THIC_MYCTU (547 aa), fasta scores; opt: 143 z-score: 272.4 E(): 6.4e-08, 53.1% identity in 49 aa overlap. Note that this gene appears to have been interrupted by the integration of the upstream element. | 0.841 |
SCO2104 | SCO5178 | gene:17759702 | gene:17762827 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 2SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain. | 0.868 |
SCO2104 | SCO5211 | gene:17759702 | gene:17762862 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.924 |
SCO2104 | SCO5562 | gene:17759702 | gene:17763220 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Putative thiamine monphosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.955 |
SCO2104 | SCO5563 | gene:17759702 | gene:17763221 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.999 |
SCO2104 | SCO6149 | gene:17759702 | gene:17763808 | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | Putative ATP GTP-binding protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.914 |
SCO2107 | SCO2104 | gene:17759705 | gene:17759702 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.886 |
SCO2107 | SCO2108 | gene:17759705 | gene:17759706 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | 0.965 |
SCO2107 | SCO2109 | gene:17759705 | gene:17759707 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.999 |
SCO2107 | SCO5178 | gene:17759705 | gene:17762827 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | 2SC3B6.02, possible sulfurylase, len: 392 aa; similar to TR:AAF33130 (EMBL:AF196567) Pseudomonas stutzeri putative sulfurylase, 391 aa; fasta scores: opt: 1433 z-score: 1624.0 E(): 0; 56.2% identity in 395 aa overlap and to SW:MOEB_ECOLI (EMBL:M21151) Escherichia coli molybdopterin biosynthesis MoeB protein, 249 aa; blastp socres: Score = 526 (185.2 bits), Expect = 1.1e-50, P = 1.1e-5, Identities = 106/249 (42%), Positives = 156/249 (62%). Contains Pfam match to entry PF00899 ThiF_family, ThiF family and PF00581 Rhodanese, Rhodanese-like domain. | 0.542 |
SCO2107 | SCO5562 | gene:17759705 | gene:17763220 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | Putative thiamine monphosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.658 |
SCO2107 | SCO5563 | gene:17759705 | gene:17763221 | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | Phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. | 0.745 |
SCO2108 | SCO2104 | gene:17759706 | gene:17759702 | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | Putative thiamin phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.973 |
SCO2108 | SCO2107 | gene:17759706 | gene:17759705 | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | SC6E10.01, possible oxidoreductase, partial CDS, len: >375 aa; similar to TR:O85228 (EMBL:AF053760), HcnC, Pseudomonas fluorescens hydrogen cyanide synthase (417 aa), fasta scores; opt: 511 z-score: 564.8 E(): 3.9e-24, 30.7% identity in 348 aa overlap, although they are more divergent at the N-terminus. Also similar to many other oxidoreductases and hypothetical proteins; SC2C1A.03, possible oxidoreductase, partial CDS, len: > 40 aa. Similar to Bacillus subtilis SW:DLD2_BACSU(EMBL:D84432) dihydrolipoamide dehydrogenase (EC 1.8.1.4) (474 aa), fasta scores opt: 111 z-score: 145.4 E(): 0. [...] | 0.965 |
SCO2108 | SCO2109 | gene:17759706 | gene:17759707 | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | Putative thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.999 |
SCO2108 | SCO3928 | gene:17759706 | gene:17761555 | SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). | Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.875 |