STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)    
Predicted Functional Partners:
SCO0434
SCF51A.12, malX, sugar phosphotransferase, len: 549 aa. Highly similar to Escherichia coli SW:PTOA_ECOLI (EMBL; M60722) PTS system, maltose and glucose-specific II ABC component (maltose and glucose-permease II ABC component) (phosphotransferase enzyme II, ABC component) (EC 2.7.1.69) (523 aa), fasta scores opt: 1852 z-score: 2064.1 E():0 59.5% identity in 543 aa overlap. Contains a Pfam match to entry PF00367 PTS_EIIB, phosphotransferase system, EIIB and a Prosite hit to PS01035 PTS EIIB domains cysteine phosphorylation site signature. Contains multiple possible membrane spanning hydr [...]
  
 0.989
SCO2127
Hypothetical protein; Involved in glucose transport or metabolism.
     
 0.963
SCO5059
SCBAC20F6.02, ppgK, polyphosphate glucokinase, len: 246 aa; highly similar to SW:PPGK_MYCTU (EMBL:U44834) Mycobacterium tuberculosis polyphosphate glucokinase (EC 2.7.1.63) PpgK or RV2702 or MTCY05A6.23, 265 aa; fasta scores: opt: 912 Z-score: 1042.8 bits: 200.5 E(): 1.7e-50; 57.322% identity in 239 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family.
  
  
0.937
SCO0063
SCJ4.44c, possible glucokinase, len: 311 aa; similar to many eg. SW:GLK_STRCO glucokinase from Streptomyces coelicolor (317 aa) fasta scores; opt: 175, z-score: 195.7, E(): 0.0015, (28.2% identity in 326 aa overlap). Contains Pfam match to entry PF00480 ROK, ROK family.
  
  
0.930
SCO2393
Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
 
  
 0.930
SCO7443
Phosphoglucomutase; SC6D11.39, pgm, phosphoglucomutase (EC 5.4.2.2), len: 546 aa. Highly similar to many phosphoglucomutases e.g. Escherichia coli SW:PGMU_ECOLI(EMBL:U08369) phosphoglucomutase (EC 5.4.2.2) (546 aa), fasta scores opt: 2216 z-score: 2396.0 E():0 60.8% identity in 538 aa overlap. Contains a Prosite hit to PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature and a Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase.
    
 0.930
SCO6110
SCBAC1A6.34c, probable sugar kinase, len: 308 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) Glk or SC6E10.20c, 317 aa; fasta scores: opt: 391 z-score: 407.0 E(): 4.3e-15; 34.4% identity in 314 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and match to Prosite entry PS01125 ROK family signature.
  
  
 
0.925
SCO4285
SCD95A.18, possible sugar kinase, len: 326 aa; similar to TR:CAB60179 (EMBL:AL132824) Streptomyces coelicolor putative sugar kinase SCAH10.25, 382 aa; fasta scores: opt: 449 z-score: 453.3 E(): 8.7e-18; 37.2% identity in 301 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and 5x degenerate repeat: (S/A)AP.
  
  
 
0.924
SCO1942
SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...]
  
 
 0.921
SCO6659
SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266.
  
 
 0.921
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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