STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO23883-oxoacyl-[acyl-carrier-protein] synthase III; Essential enzyme that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (343 aa)    
Predicted Functional Partners:
SCO2387
SC4A7.15, fabD, malonyl CoA:acyl carrier protein malonyltransferase, len: 316 aa; identical to previously sequenced TR:P72391 (EMBL:X86475) Streptomyces coelicolor malonyl CoA:acyl carrier protein malonyltransferase, FabD, 316 aa and similar to SW:FABD_ECOLI (EMBL:M87040) Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) FabD, 308 aa; fasta scores: opt: 524 z-score: 551.4 E(): 2.5e-23; 36.8% identity in 315 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain.
 
 
 0.999
SCO2390
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
 0.994
SCO4921
SCK13.13c, accA2, putative acyl-CoA carboxylase complex A subunit, len: 590 aa; identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit AccA2, 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site.
 
 
 0.955
SCO1266
2SCG18.13c, fabF2, probable 3-oxoacyl-[acyl-carrier-protein] synthase II, len: 422 aa; highly similar to TR:O54149 (EMBL:AL021409) Streptomyces coelicolor 3-oxoacyl-[acyl-carrier-protein] synthase SC3F7.06c, 407 aa; fasta scores: opt: 1476 z-score: 1594.4 E(): 0; 57.6% identity in 403 aa overlap and to SW:FABF_ECOLI (EMBL:Z34979) Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase II (EC 2.3.1.41) (KASII) FabF, 412 aa; fasta scores: opt: 976 z-score: 1056.0 E(): 0; 38.9% identity in 406 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase; Belon [...]
 
 
 0.952
SCO2777
SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...]
 
 
 0.951
SCO0548
SCF11.28c, fabB2, possible 3-oxoacyl-(acyl-carrier-protein) synthase, len: 428 aa; similar to TR:Q54208 (EMBL:L43074) Streptomyces glaucescens fabB, 423 aa; fasta scores: opt: 1375 z-score: 1459.4 E(): 0; 52.1% identity in 420 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.950
SCO3248
SCE29.17c, fabF3, probable 3-oxoacyl-[acyl carrier protein] synthase II, len: 406 aa; similar to many e.g. TR:O54149 (EMBL:AL021409) 3-oxoacyl acyl carrier protein synthase II from the Red cluster of Streptomyces coelicolor (407 aa) fasta scores; opt: 1217, z-score: 1314.2, E(): 0, (50.1% identity in 407 aa overlap) and SW:FABF_ECOLI 3-oxoacyl-[acyl carrier protein] synthase II FabF, from Escherichia coli (412 aa) fasta scores; opt: 843, z-score: 912.2, E(): 0, (35.4% identity in 404 aa overlap). Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase, score 92.60, E [...]
 
 
 0.942
SCO2445
SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap.
 
  
 0.936
SCO1815
Probable 3-oxacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.925
SCO4501
SCD35.08c, probable bifunctional protein (ketoreductase/3-oxoacyl-[acyl-carrier protein] reductase), len: 430 aa; highly similar to TR:O53665 (EMBL:AL021929) Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] reductase MTV034.08c, 454 aa; fasta scores: opt: 1227 z-score: 1186.5 E(): 0; 50.8% identity in 455 aa overlap, N-terminal region similar to TR:O86480 (EMBL:AJ007932) Streptomyces argillaceus ketoreductase MtmTII, 253 aa; blastp results: Identities = 54/204 (26%), Positives = 87/204 (42%) and C-terminal region to SW:FABG_ECOLI (EMBL:M84991) Escherichia coli 3-oxoacyl-[acy [...]
 
 
 0.905
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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