STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2468DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (641 aa)    
Predicted Functional Partners:
SCO3911
Putative replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 0.983
SCO2470
SC7A8.09c, probable deoxyguanosine triphosphate triphosphohydrolase, len: 424 aa; similar to TR:O52199 (EMBL:AF027507) Mycobacterium smegmatis dDGTPase Dgt, 428 aa; fasta scores: opt: 1272 z-score: 1453.2 E(): 0; 51.9% identity in 430 aa overlap and similar to N-terminus of SW:DGTP_ECOLI (EMBL:M31772) Escherichia coli deoxyguanosine triphosphate triphosphohydrolase Dgt, 504 aa; fasta scores: opt: 128 z-score: 147.9 E(): 0.76; 34.1% identity in 255 aa overlap; Belongs to the dGTPase family. Type 2 subfamily.
 
   
 0.896
SCO2465
RNA polymerase principal sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.890
SCO5624
SC2E1.41, rpsB, 30S ribosomal protein S2, len: 310 aa; almost identical to RS2_STRCO 30S ribosomal protein S2 (242 aa), E(): 0, 96.7% identity in 242 aa overlap and also highly similar to many others e.g. RS2_ECOLI 30S ribosomal protein S2 (240 aa), fasta scores; opt: 744 z-score: 950.7 E(): 0, 50.4% identity in 224 aa overlap. Contains PS00962 Ribosomal protein S2 signature 1 and PS00211 ABC transporters family signature (probably a false positive). Also contains Pfam matches to entry S2 PF00318, Ribosomal protein S2, score 304.89 and to entry 60s_ribosomal PF00428, 60s Acidic ribosom [...]
 
  
 0.878
SCO2904
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
    
 
 0.874
SCO3528
Conserved hypothetical protein; SCE2.09, unknown, len: 386 aa; weak similarity to several predicted helicases e.g. SW:DNAB_TREPA replicative DNA helicase from Treponema pallidum (438 aa) fasta scores; opt: 188, z-score: 190.6, E(): 0.0027, (36.5% identity in 156 aa overlap) and similar to TR:Q9L1W8 (EMBL:AL138667) Streptomyces coelicolor hypothetical protein SC3D9.11c, 372 aa; fasta scores: opt: 559 Z-score: 528.6 E(): 8.2e-22; 37.466% identity in 363 aa overlap.
  
 
 0.857
SCO6843
Conserved hypothetical protein SC3D9.11c; SC3D9.11c, unknown, len: 372 aa. Weakly similar to Streptomyces coelicolor TR:Q9X8A4 (EMBL:AL049645) hypothetical protein, SCE2.09 (386 aa), fasta scores opt: 559 z-score: 616.2 E(): 6.5e-27; 37.5% identity in 363 aa overlap.
  
 
 0.857
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 
 0.849
SCO2966
Small protein B homologue; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switch [...]
  
   
 0.835
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
 
  
 0.833
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (14%) [HD]