STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2490SC7A8.29, probable dehydrogenase (putative secreted protein), len: 255 aa; similar to TR:O88068 (EMBL:AL031541) Streptomyces coelicolor putative dehydrogenase SCI35.33c, 260 aa; fasta scores: opt: 536 z-score: 554.4 E(): 1.7e-23; 40.0% identity in 255 aa overlap and to SW:DHG2_BACSU (EMBL:AB000617)Bacillus subtilis glucose 1-dehydrogenase II (EC 1.1.1.47) (GlcDH-II) (Gdh-II) (general stress protein 74) (Gsp74) YcdF, 258 aa; fasta scores: opt: 566 z-score: 584.7 E(): 3.5e-25; 39.3% identity in 252 aa overlap Contains two Pfam matches to entries PF00106 adh_short, short chain dehydrogena [...] (255 aa)    
Predicted Functional Partners:
SCO1127
2SCG38.20, probable oxidoreductase, len: 312 aa; similar to SW:BDHA_RHIME (EMBL:AF080548) Rhizobium meliloti D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) BdhA, 258 aa; fasta scores: opt: 332 z-score: 358.5 E(): 1.6e-12; 32.7% identity in 223 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
   0.771
SCO2486
SC7A8.25, nirB, probable nitrite reductase, len: 410 aa; similar to N-terminal region of TR:O53674 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase large subunit NirB, 853 aa; fasta scores: opt: 657 z-score: 711.6 E(): 3e-32; 37.8% identity in 431 aa overlap and to SW:NIRB_KLEPN (EMBL:L06800) Klebsiella pneumoniae nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NasB, 957 aa; fasta scores: opt: 636 z-score: 688.3 E(): 6e-3; 35.4% identity in 412 aa overlap. Contains possible N-terminal region signal peptide sequence.
  
    0.756
SCO2487
SC7A8.26, nirB, probable nitrite reductase large subunit, len: 871 aa; similar to TR:Q00943 (EMBL:Z68122) Pichia angusta nitrite reductase Yni1, 1044 aa; fasta scores: opt: 1960 z-score: 2117.6 E(): 0; 43.2% identity in 868 aa overlap and SW:NIRB_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NirB 847 aa; fasta scores:opt: 1609 z-score: 1739.1 E(): 0; 52.1% identity in 845 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase and two matches to Prosite entries PS00136 Serine proteases, subtilase family, asp [...]
  
    0.755
SCO2488
SC7A8.27, nirC, probable nitrite reductase small subunit, len: 131 aa; similar to TR:O53675 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase small subunit NirD, 118 aa; fasta scores: opt: 353 z-score: 455.1 E(): 5.9e-18; 56.5% identity in 92 aa overlap and to SW:NIRD_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] small subunit (EC 1.6.6.4) NirD, 108 aa; fasta scores: opt: 265 z-score: 346.0 E(): 7e-12; 46.9% identity in 96 aa overlap.
  
    0.752
SCO2489
SC7A8.28, probable tetR-family transcriptional regulator, len: 194 aa; similar to TR:CAB53122 (EMBL:AL109962) Streptomyces coelicolor putative transcriptional regulatory protein SCJ1.04, aa; fasta scores: opt: 184 z-score: 231.2 E(): 1.7e-05; 30.9% identity in 162 aa overlap and to SW:YCFQ_ECOLI (EMBL:AE000211) Escherichia coli hypothetical transcriptional regulator in NDH-MFD intergenic region YcfQ, 210 aa; fasta scores: opt: 282 z-score: 348.3 E(): 5.2e-12; 32.3% identity in 192 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and poss [...]
       0.630
SCO1692
SCI30A.13c, possible oxidoreductase, len: 256 aa; similar to many e.g. SW:FABG_ECOLI 3-oxoacyl-(carrier protein) reductase from Escherichia coli (244 aa) fasta scores; opt: 239, z-score: 270.9, E(): 9.2e-08, (27.3% identity in 198 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature.
  
 
   0.603
SCO4228
Putative phosphate transport system regulator; Plays a role in the regulation of phosphate uptake.
   
 
 0.531
SCO3124
Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.530
SCO4139
Phosphate ABC transport system ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
      
 0.518
SCO4684
SCD31.09, scoF3, cold shock protein, len: 67 aa; highly similar to TR:O54117 (EMBL:AL021529) Streptomyces coelicolor cold-shock domain protein SC10A5.26c, 67 aa; fasta scores: opt: 432 z-score: 604.3 E(): 3.1e-26; 97.0% identity in 67 aa overlap and to SW:CSPF_STRCO (EMBL:X92686) Streptomyces coelicolor cold shock protein ScoF, 67 aa; fasta scores: opt: 370 z-score: 520.7 E(): 1.4e-21; 80.6% identity in 67 aa overlap. Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain and match to Prosite entry PS00352 'Cold-shock' DNA-binding domain signature.
   
 
 0.515
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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