STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2510Conserved hypothetical protein SCC121.13c; Involved in DNA repair and RecF pathway recombination. (251 aa)    
Predicted Functional Partners:
SCO3618
Putative recomination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
 
 0.988
SCO2509
Undecaprenyl phosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
  
 0.949
SCO2539
Era-like GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
  
  
 0.946
SCO3355
SCE94.06, mutY, putative adenine glycosylase, len: 308 aa; previously partially sequenced therefore partially identical to TR:E1358524 (EMBL:AJ131213) MutY, putative adenine glycosylase from Streptomyces coelicolor (183 aa) fasta scores; opt: 1220, z-score: 1357.4, E(): 0, (100.0% identity in 183 aa overlap). Also similar to many others e.g. SW:MUTY_SALTY MutY, adenine glycosylase from Salmonella typhimurium (350 aa) fasta scores; opt: 500, z-score: 558.7, E(): 8.3e-24, (39.4% identity in 231 aa overlap). Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III.
     
 0.883
SCO5573
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
      
 0.875
SCO2511
Hypothetical protein SCC121.14c; SCC121.14c, unknown, len: 73 aa.
       0.867
SCO2512
Hypothetical protein SCC121.15c; SCC121.15c, unknown, len: 68 aa.
       0.867
SCO5769
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
      
 0.866
SCO5770
RecX, putative regulatory protein; Modulates RecA activity; Belongs to the RecX family.
 
  
 0.849
SCO3876
DNA replication protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
    
 
 0.842
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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