STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2533Conserved hypothetical protein SCC117.06; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)    
Predicted Functional Partners:
SCO2532
SCC117.05, PhoH-like protein, len: 359 aa. Highly similar to many including: Escherichia coli SW:PHOH_ECOLI (EMBL:D10391) phosphate starvation-inducible protein PhoH protein (354 aa), fasta scores opt: 583 z-score: 650.4 E(): 7.8e-29 37.7% identity in 321 aa overlap and Mycobacterium tuberculosis SW:PHOL_MYCTU(EMBL:Z95208) PhoH-like protein (352 aa), fasta scores opt: 1407 z-score: 1560.0 E():0 63.6% identity in 349 aa overlap. Contains a Prosite hit to PS00017 ATP/GTP-binding site motif A (P-loop).
  
  
 0.983
SCO2539
Era-like GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
 
  
 0.941
SCO2597
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
 
 
 0.930
SCO0618
SCF56.02, hypothetical protein, len: 461 aa; similar to various hypothetical proteins, e.g. TR:BAA86645 (EMBL:AB033763) Staphylococcus aureus hypothetical 49.4 kD protein, 442 aa; fasta scores: opt: 286 z-score: 318.4 E(): 2.3e-10; 26.6% identity in 466 aa overlap.
  
 
 0.921
SCO4730
SC6G4.08, rplQ, 50S ribosomal protein L17, len: 168 aa; highly similar to many e.g. RL17_BACST 50S ribosomal protein L17 (119 aa), fasta scores; opt: 339 z-score: 597.2 E (): 5.3e-26, 47.4% identity in 116 aa overlap. Contains approx 50 aa C-terminal extension, not present in other RplQ.
 
 
 
 0.921
SCO4711
30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
 
 
 
 0.920
SCO2534
Putative membrane protein; SCC77.01, unknown, partial CDS, len: > 110 aa. Highly similar to a protein of undefined function from Mycobacterium tuberculosis SW:Y1DE_MYCTU(EMBL:Z95208) (435 aa), fasta scores opt: 290 z-score: 369.6 E(): 3.4e-13 54.0% identity in 100 aa overlap. Overlaps and extends into CDS SCC117.07 on the adjoining cosmid; SCC117.07, possible membrane protein, partial CDS, len: > 358 aa. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis SW:YN66_MYCTU(EMBL:Z95208) hypothetical 47.2 KD protein (435 aa), fasta scores opt: 1159 z-scor [...]
  
  
 0.914
SCO4721
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
 
 0.908
SCO0999
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
   
 
 0.904
SCO2633
Superoxide dismutase [Fe-Zn] (EC 1.15.1.1); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
   
 
 0.904
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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