STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO2569Conserved hypothetical protein SCC123.07c; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. (281 aa)    
Predicted Functional Partners:
SCO5565
SC7A1.09, unknown, len: 589 aa; similar to several hypothetical proteins eg.TR:O34751 (EMBL:Z99112) YLOV protein from Bacillus subtilis (553 aa) fasta scores; opt: 656, z-score: 464.3, E(): 1.4e-18, (28.9% identity in 582 aa overlap) and to TR:AAK47378 (EMBL:AE007126) Mycobacterium tuberculosis CDC1551 hypothetical protein MT3052, 470 aa; fasta scores: opt: 772 Z-score: 726.0 E(): 8.3e-33; 40.974% identity in 493 aa overlap.
 
 0.988
SCO2568
SCC123.06c, possible DNA-binding protein, len: 355 aa. Similar to Mycobacterium tuberculosis TR:P71728 (EMBL:Z81368) hypothetical 30.5 KD protein (297 aa), opt: 271 z-score: 260.6 E(): 4e-07 36.3% identity in 292 aa overlap. Also similar in parts to Bacillus subtilis SW:CME1_BACSU (EMBL:L15202) ComE operon protein 1, required for the binding and uptake of transforming DNA (205 aa), fasta scores opt: 295 z-score: 284.5 E(): 1.9e-08 32.2% identity in 180 aa overlap. Contains a Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif and a possible membrane spanning hydrophobic domain.
 
     0.789
SCO2570
Putative secreted protein; SCC123.08c, possible secreted protein, len: 258 aa. Contains a possible N-terminal signal sequence.
       0.785
SCO2567
SCC123.05c, possible integral membrane protein, len: 855 aa. Similar to Bacillus subtilis SW:CME3_BACSU(EMBL:L15202) ComE operon protein 3, required for the binding and uptake of transforming DNA (776 aa), fasta scores opt: 355 z-score: 368.7 E(): 3.8e-13 26.3% identity in 635 aa overlap and Mycobacterium tuberculosis TR:P71729(EMBL:Z81368) hypothetical 52.8 KD protein (514 aa), fasta scores opt: 450 z-score: 470.1 E(): 8.5e-19 35.2% identity in 546 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
       0.762
SCO2571
SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V).
       0.698
SCO2565
Hypothetical protein SCC123.03c; SCC123.03c, unknown, len: 73 aa.
       0.451
SCO6966
Putative lipase; SC6F7.19c, possible lipase, len: 269 aa. Similar to many other putative lipases e.g. Thermotoga maritima TR:Q9X171(EMBL:AE001789) lipase, putative (259 aa), fasta scores opt: 345 z-score: 396.1 E(): 1.3e-14 33.1% identity in 239 aa overlap. contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
     
 0.443
SCO5482
Hypothetical protein SC2A11.16; SC2A11.16, unknown, len: 340 aa; some similarity to M. tuberculosis hypothetical protein YV25_MYCTU MTCY20G9.25, Rv0499 (291 aa), fasta scores; opt: 240 z-score: 316.7 E(): 2.2e-10, 28.9% identity in 270 aa overlap.
  
    0.417
SCO3320
Conserved hypothetical protein; Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance; Belongs to the transcriptional regulatory Rex family.
  
   
 0.402
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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