STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2611SCC88.22c mreB, rod shape-determining protein, len: 343 aa; identical to previously sequenced TR:O33619 (EMBL:Y14206) Streptomyces coelicolor MreB protein, 342 aa and similar to SW:MREB_BACSU (EMBL:M95582) Bacillus subtilis rod shape-determining protein MreB, 337 aa; fasta scores: opt: 1346 z-score: 1516.0 E(): 0; 63.0% identity in 330 aa overlap. (343 aa)    
Predicted Functional Partners:
SCO2610
SCC88.21c, mreC, rod shape-determining protein, len: 341 aa; identical to previously sequenced TR:O33620 (EMBL:Y14206) Streptomyces coelicolor MreC protein, 366 aa and similar to SW:MREC_ECOLI (EMBL:M31792) Escherichia coli rod shape-determining protein MreC, 367 aa; fasta scores: opt: 258 z-score: 276.5 E(): 5.5e-08; 24.4% identity in 336 aa overlap. Contains possible coiled-coil region and possible N-terminal region signal peptide sequence.
 
 
 0.998
SCO2608
SCC88.19c, pbp2, penicillin binding protein, len: 769 aa; almost identical to previously sequenced TR:O33622 (EMBL:Y14206) Streptomyces coelicolor Pbp protein and similar to SW:PBP2_ECOLI (EMBL:X04516) Escherichia coli penicillin-binding protein 2 (Pbp-2), 633 aa; fasta scores: opt: 226 z-score: 236.5 E(): 9.3e-06; 27.9% identity in 692 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain.
 
 
 
 0.979
SCO2607
SCC88.18c, sfr, Sfr protein, len: 372 aa; identical to previously sequenced TR:O33623 (EMBL:Y14206) Streptomyces coelicolor Sfr protein and similar to SW:SP5E_BACSU (EMBL:X51419) Bacillus subtilis stage V sporulation protein E, SpoVE, 366 aa; fasta scores: opt: 795 z-score: 897.2 E(): 0; 39.4% identity in 363 aa overlap. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein and match to Prosite entry PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. Contains also possible hydrophobic membrane spanning regions; Belongs to the SEDS family.
 
 
 0.977
SCO2609
SCC88.20c, mreD, rod shape-determining protein, len: 223 aa; identical to previously sequenced TR:O33621 (EMBL:Y14206) Streptomyces coelicolor MreD protein, 223 aa and similar to TR:O83512 (EMBL:AE001226) Treponema pallidum rod shape-determining protein (MreD), 168 aa; fasta scores: opt: 135 z-score: 162.4 E(): 0.13; 24.8% identity in 161 aa overlap. Contains possible N-terminal region signal peptide sequence.
 
  
 0.973
SCO2082
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 0.966
SCO5751
SC7C7.06, putative membrane protein, len: 287 aa. Contains possible hydrophobic membrane spanning region.
 
 
 0.924
SCO2090
SC4A10.23c, ftsI, cell division protein, len: 654 aa; previously sequenced as TR:Q9Z5V7 (EMBL:AF123319), FtsI, Streptomyces coelicolor cell division protein (651 aa) and identical to that sequence, but with a different putative start codon. C-terminal end shares weak similarity with others from S.coelicolor e.g. SC6G9.32 (EMBL:AL079356) S.coelicolor possible penicillin-binding protein (485 aa) (29.3% identity in 447 aa overlap). Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domai [...]
 
 
 
 0.912
SCO2085
SC4A10.18c, ftsW, probable cell division protein, len; 456 aa; previously sequenced as TR:Q9ZBA6 (EMBL:U10879), ftsW, Streptomyces coelicolor ftsW protein (456 aa) and identical to that sequence. Similar to many members of the ftsW/rodA/spoVE family e.g. SW:SP5E_BACSU (EMBL:X51419), spoVE, Bacillus subtilis stage V sporulation protein (366 aa), fasta scores; opt: 745 z-score: 788.4 E(): 0, 36.9% identity in 350 aa overlap. Shows similarity to SC6G9.31 (EMBL:AL079356) S.coelicolor probable integral membrane cell-cycle protein (446 aa) (30.0% identity in 416 aa overlap) and SCH69.16 (EMB [...]
 
 
 0.852
SCO4301
SCD95A.34c, possible DNA-binding protein, len: 279 aa; similar to various S. coelicolor hypothetical proteins, e.g. TR:CAB69734 (EMBL:AL137166) Streptomyces coelicolor hypothetical 30.4 kD protein SCC121.16, 277 aa; fasta scores: opt: 731 z-score: 897.3 E(): 0; 45.2% identity in 259 aa overlap and to TR:CAB88448 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 388 z-score: 478.8 E(): 3.3e-19; 34.3% identity in 286 aa overlap. Contains TTA leucine codon, possible target for bldA regulation and a possible helix-turn-helix motif at r [...]
  
 
 0.847
SCO6166
Hypothetical protein SC6C5.02; SC6C5.02, unknown, len: 272aa.
  
   
 0.847
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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