STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2666SC6D10.09, possible serine/threonine protein kinase, len: 903 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 1045 z-score: 821.3 E(): 0; 42.0% identity in 793 aa overlap and to SW:PKN2_MYXXA (EMBL:M94857) Myxococcus xanthus serine/threonine-protein kinase Pkn2 (EC 2.7.1.-), 830 aa; fasta scores: opt: 301 z-score: 243.3 E(): 3.8e-06; 28.9% identity in 433 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and match to Prosite entry PS00402 Binding-protein-depe [...] (903 aa)    
Predicted Functional Partners:
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.974
SCO2663
SC6D10.06, possible secreted protein, len: 429 aa; similar to TR:P96258 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 47.1 kD protein MTCY22G10.08c, 439 aa; fasta scores: opt: 430 z-score: 482.8 E(): 1.8e-19; 30.9% identity in 427 aa overlap and to TR:Q9ZBL6 (EMBL:AL035159) Mycobacterium leprae putative membrane protein MLCB1450.21c, 403 aa; fasta scores: opt: 412 z-score: 463.3 E(): 2.1e-18; 29.6% identity in 423 aa overlap. Contains possible N-terminal region signal peptide sequence.
 
  
 0.954
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
   
 
 0.953
SCO2664
SC6D10.07, possible sugar-binding protein, len: 352 aa; similar to TR:O34563 (EMBL:Z99117) Bacillus subtilis glutamine ABC transporter (glutamine-binding protein) GlnH, 27 33; fasta scores: opt: 474 z-score: 507.4 E(): 7.5e-21; 32.6% identity in 285 aa overlap and to SW:GLNH_BACST (EMBL:M61017) Bacillus stearothermophilus glutamine-binding protein precursor GlnH, 262 aa; fasta scores: opt: 414 z-score: 444.6 E(): 2.4e-17; 33.1% identity in 236 aa overlap. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, to Prosite entry PS01039 [...]
 
  
 0.947
SCO2668
SC6D10.11, hypothetical protein, len: 452 aa; similar to TR:Y103_SYNY3 (EMBL:D64004) Synechocystis sp. hypothetical 45.8 kD protein SLL0103, 420 aa; fasta scores: opt: 265 z-score: 295.0 E(): 5.1e-09; 26.6% identity in 354 aa overlap.
 
  
 0.928
SCO2665
Hypothetical protein SC6D10.08; SC6D10.08, unknown, len: 444 aa. Contains possible coiled-coil region.
 
   
 0.865
SCO2669
Hypothetical protein SC6D10.12; SC6D10.12, unknown, len: 604 aa. Glycine and proline rich. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.860
SCO7298
Putative thioredoxin reductase; SC5F8.08c, possible thioredoxin reductase, len: 558 aa. The C-terminus of this protein is highly similar to many thioredoxin reductases including: Streptomyces clavuligerus SW:TRXB_STRCL(EMBL:Z21946) thioredoxin reductase (EC 1.6.4.5) (321 aa), fasta scores opt: 494 z-score: 519.8 E(): 1.7e-21 32.8% identity in 332 aa overlap. The N-terminus is similar to the receiver domains of many response regulators e.g. Alcaligenes eutrophus SW:HOXA_ALCEU(EMBL:M64593) hydrogenase transcriptional regulatory protein, HoxA (482 aa) (32% identity over a 117 aa overlap). [...]
  
 
 0.801
SCO1467
SCL6.24c, hypothetical protein, len: 491 aa; similar to TR:CAB71206 (EMBL:AL138538) Streptomyces coelicolor hypothetical 47.0 kD protein SC6D10.11, 452 aa; fasta scores: opt: 835 z-score: 861.3 E(): 0; 37.6% identity in 434 aa overlap.
 
    0.779
SCO4296
Chaperonin 2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.722
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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