STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2725SCC46.10, possible lipoprotein, len: 285 aa; identical to previously sequenced TR:Q53936 (EMBL:L48550) Streptomyces coelicolor unknown protein downstream of msdA. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal signal peptide sequence. (285 aa)    
Predicted Functional Partners:
SCO4691
SCD31.16, possible membrane protein, len: 197 aa; similar to C-terminal region of TR:Q9WX28 (EMBL:AL079345) Streptomyces coelicolor putative membrane protein SCE68.03, 441 aa; fasta scores: opt: 495 z-score: 618.7 E(): 5e-27; 41.5% identity in 205 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.666
SCO7754
SC5E9.02, possible anti-sigma factor antagonist, len: 127aa; weakly similar to many eg. SW:Q9WVX8 (RSBV_STRCO) anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa) fasta scores; opt: 118, z-score: 164.6, E(): 0.11, 27.7% identity in 94 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain.
  
     0.605
SCO3905
SCH24.27c, putative membrane protein, len: 101 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning regions.
  
     0.603
SCO4647
Transcription antitermination protein; Participates in transcription elongation, termination and antitermination.
       0.560
SCO4648
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
       0.560
SCO4649
50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
       0.560
SCO4652
50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
       0.560
SCO4653
50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.
       0.560
SCO7358
Hypothetical protein SC9H11.12c; SC9H11.12c, unknown, len: 500 aa.
  
     0.549
SCO2493
SC7A8.32c, probable membrane protein, len: 402 aa; similar to TR:Q9WX28 (EMBL:AL079345) Streptomyces coelicolor putative membrane protein SCE68.03, 441 aa; fasta scores: opt: 1057 z-score: 1265.9 E(): 0; 44.8% identity in 384 aa overlap and SW:MDMB_STRMY (EMBL:M93958) Streptomyces mycarofaciens acyltransferase (EC 2.3.1.-) MdmB, 387 aa; fasta scores: opt: 211 z-score: 255.4 E(): 7.8e-07; 25.6% identity in 406 aa overlap.
  
     0.515
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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