STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3070SCE25.11c, probable chlorohydrolase, len: 391 aa; similar to SW:HUTI_BACSU (EMBL:D31856) Bacillus subtilis imidazolonepropionase (EC 3.5.2.7) (imidazolone-5-propionate hydrolase) HutI, 421 aa; fasta scores: opt: 659 z-score: 767.1 E(): 0; 36.1% identity in 404 aa overlap. Contains Pfam match to entry PF01685 ATZ_TRZ, Chlorohydrolase; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (391 aa)    
Predicted Functional Partners:
SCO3073
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 
 0.999
SCO4932
SCK13.24, hutH, histidine ammonia-lyase, len: 512 aa; highly similar to SW:HUTH_STRGR (EMBL:M77841) Streptomyces griseus histidine ammonia-lyase (EC 4.3.1.3) HutH, 516 aa; fasta scores: opt: 2928 z-score: 3294.6 E(): 0; 88.5% identity in 513 aa overlap. Contains Pfam match to entry PF00221 PAL, Phenylalanine and histidine ammonia-lyases and matches to Prosite entries PS00217 Sugar transport proteins signature 2 and PS00488 Phenylalanine and histidine ammonia-lyases signature; Belongs to the PAL/histidase family.
 
  
 0.997
SCO3071
SCE25.12c, possible chlorohydrolase, len: 449 aa; similar to SW:ATZA_PSESD (EMBL:U55933) Pseudomonas sp. atrazine chlorohydrolase (EC 3.8.1.-) AtzA, 473 aa; fasta scores: opt: 401 z-score: 468.3 E(): 1.3e-18; 26.9% identity in 428 aa overlap. Contains Pfam match to entry PF01685 ATZ_TRZ, Chlorohydrolase.
 
  
 0.936
SCO3072
SCE25.13c, probable amino acid hydrolase, len: 400 aa; similar to SW:AMB2_BACST (EMBL:S67784) Bacillus stearothermophilus N-carbamyl-L-amino acid amidohydrolase (EC 3.5.1.-) AmaB, 409 aa; fasta scores: opt: 733 z-score: 804.8 E(): 0; 34.7% identity in 404 aa overlap.
 
     0.835
SCO3069
SCE25.10c, possible integral membrane protein, len: 114 aa. Contains possible hydrophobic membrane spanning regions.
       0.831
SCO0315
SC5G9.24c, probable decarboxylase, len: 452 aa; similar to many e.g. SW:DCDA_BACSU (EMBL:L09228), LysA, Bacillus subtilis diaminopimelate decarboxylase (441 aa), fasta scores; opt: 484 z-score: 542.1 E(): 7.9e-23, 31.6% identity in 389 aa overlap. Similar to TR:Q9ZBH5 (EMBL:AL035206), DcdA, Streptomyces coelicolor diaminopimelate decarboxylase (440 aa), fasta scores; opt: 400 z-score: 384.5 E(): 3.6e-16, 30.2% identity in 427 aa overlap. Contains 2 Pfam matches to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2 a [...]
     
 0.707
SCO6999
Hypothetical protein SC8F11.25c; SC8F11.25c, unknown, len: 265 aa.
  
  
 0.598
SCO0682
Hypothetical protein SCF15.03c; SCF15.03c, unknown, len: 124 aa. Contains a probable coiled-coil between residues 96..124 (29 residues).
       0.560
SCO0683
SCF15.04c, hypothetical protein, len: 174 aa. Weakly similar to several conserved proteins of undefined function e.g. Methanococcus jannaschii SW:Y714_METJA(EMBL:U67518) hypothetical protein (118 aa), fasta scores opt: 182 z-score: 196.7 E(): 0.0014 30.4% identity in 115 aa overlap.
       0.560
SCO0684
Hypothetical protein SCF15.05c; SCF15.05c, unknown, len: 258 aa.
       0.560
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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