STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3180Molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (170 aa)    
Predicted Functional Partners:
SCO1821
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
 
 0.999
SCO3179
SCE87.30c, moaB, probable molybdenum cofactor biosynthesis protein (putative secreted protein), len: 179 aa. Highly similar to many including: Mycobacterium tuberculosis TR:O53877 (EMBL:AL022004) putative molybdopterin biosynthesis Mog protein (160 aa), fasta scores opt: 617 z-score: 660.3 E(): 2.1e-29 60.0% identity in 160 aa overlap and the C-terminus of the Synechococcus sp MoaC, MoaB fusion protein SW:MOCB_SYNP7 (EMBL:X99625) molybdenum cofactor biosynthesis protein CB (319 aa), fasta scores opt: 401 z-score: 430.6 E(): 1.3e-16 41.5% identity in 171 aa overlap. Contains a Prosite h [...]
  
 0.999
SCO5201
2SC3B6.25, moaE-like protein, len: 152 aa; similar to SW:MOAE_ECOLI (EMBL:X70420) Escherichia coli molybdopterin [mpt] converting factor, subunit 2 MoaE, 149 aa; fasta scores: opt: 255 z-score: 317.2 E(): 3.3e-10; 33.3% identity in 129 aa overlap.
 
 0.999
SCO3181
Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
 
  
 0.987
SCO3827
Putative molybdenum cofactor biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
 
  
 0.948
SCO4161
SCD84.28, possible molybdopterin converting factor, len: 84 aa; similar to TR:O53880 (EMBL:AL022004) Mycobacterium tuberculosis putative molybdopterin converting factor (subunit 1) MoaD-2, 92 aa; fasta scores: opt: 191 z-score: 269.0 E(): 1.6e-07; 45.9% identity in 85 aa overlap.
  
  
 0.885
SCO3704
SCH35.20c, possible substrate-binding transport protein, len: 269aa; similar to many egs. TR:O31229 (EMBL:Y10817) molybdate-binding periplasmic transport protein from Arthrobacter nicotinovorans (260 aa) fasta scores; opt: 613, z-score: 670.6, E(): 5e-30, (43.4% identity in 256 aa overlap) and SW:MODA_ECOLI molybdate-binding periplasmic transport protein from Escherichia coli (257 aa) fasta scores; opt: 163, z-score: 186.1, E(): 0.0049, (31.7% identity in 249 aa overlap). Contains possible N-terminal signal sequence.
 
   
 0.846
SCO4731
Putative pseudouridylate synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
     
 0.829
SCO2911
SCE19A.11c, conserved hypothetical protein, len: 92 aa; unknown function, similar to hypothetical proteins from other organisms e.g. SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (93 aa), fasta scores; opt: 341 z-score: 451.3 E(): 8.3e-18, 57.0% identity in 93 aa overlap.
  
  
 0.812
SCO4294
SCD95A.27, hypothetical protein, len: 91 aa; similar to SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical 9.6 kD protein MTCY130.20, 93 aa; fasta scores: opt: 369 z-score: 480.3 E(): 2.7e-19; 63.4% identity in 93 aa overlap, to TR:CAB50992 (EMBL:AL096852) Streptomyces coelicolor hypothetical protein SCE19A.11c, 92 aa; fasta scores: opt: 332 z-score: 416.4 E(): 1.2e-17; 54.9% identity in 91 aa overlap and highly similar to TR:Q9EUR9 (EMBL:AJ250537) Streptomyces hygroscopicus hypothetical protein, 92 aa; fasta scores: opt: 496 Z-score: 626.4 E(): 2.9e-27; 83.516% identi [...]
  
  
 0.812
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.