STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SCO3318Putative porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (319 aa)    
Predicted Functional Partners:
SCO3311
Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family.
 
 0.999
SCO3317
SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...]
 0.999
SCO3319
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.998
SCO1553
SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...]
  
 0.990
SCO2958
SCE59.17c, possible transcriptional regulator, len: 395 aa; similar to TR:P95217 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 40.7 kD protein MCTY0A4.04c, 381 aa; fasta scores: opt: 1224 z-score: 1335.3 E(): 0; 52.3% identity in 377 aa overlap and C-terminal region similar to SW:CUTR_STRCO (EMBL:X58793) Streptomyces coelicolor transcriptional regulatory protein CutR, 217 aa; fasta scores: opt: 130 z-score: 151.1 E(): 0.53; 30.3% identity in 132 aa overlap. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
  
 0.988
SCO6031
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.971
SCO4469
SCD65.12, hemL, glutamate-1-semialdehyde 2,1-aminomutase, len: 438 aa; highly similar to SW:GSA_ECOLI (EMBL:X53696) Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) HemL, 426 aa; fasta scores: opt: 1425 z-score: 1497.5 E(): 0; 52.0% identity in 425 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
 
  
 0.945
SCO7343
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 
0.917
SCO3320
Conserved hypothetical protein; Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance; Belongs to the transcriptional regulatory Rex family.
       0.875
SCO0401
SCF62.27, possible aminotransferase, len: 441 aa. Similar to many including Pseudomonas aeruginosa SW:GSA_PSEAE (EMBL:X82072) glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) (glutamate-1-semialdehyde aminotransferase) (427 aa), fasta scores opt: 475 z-score: 540.8 E(): 9.5e-23 34.8% identity in 434 aa overlap and Streptomyces coelicolor TR:CAB39702 (EMBL: AL049485) probable aminotransferase SC6A5.18 (461 aa), fasta scores opt: 464 z-score: 527.9 E(): 4.9e-22 32.4% identity in 407 aa overlap. Contains 2x Pfam matches to entry PF00202 aminotran_3, Aminotransferases class-III pyrido [...]
 
  
 0.844
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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